| Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon | |
| Alternative Title | Apoptosis of Human Pancreatic Carcinoma Cells Induced By All-Trans Retinoic Acid and Interferon |
| Wang Xiaohua; Yin Yuanqin; Ma Ping; Sui Chengguang; Meng Fandong; Jiang Youhong | |
| 2009 | |
| Source Publication | CHINESE JOURNAL OF CANCER RESEARCH
 |
| ISSN | 1000-9604 |
| Volume | 21Issue:3Pages:224-228 |
| Abstract | To investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-alpha). |
| Other Abstract | Objective: To investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-α). Methods: PC3 cells were treated with ATRA and IFN-α. The inhibitory rate of PC3 cell proliferation was detected using MTT method. Cellular apoptosis was determined with flow cytometry. The percentage of PC3 cell apoptosis was assayed using TUNEL methods. Results: ATRA and IFN-α could inhibit cellular proliferation and induces cellular apoptosis of PC3 cells. The inhibitory effect was stronger when the ATRA and IFN-α were combined as a therapy. Conclusion: ATRA inhibits the proliferation of PC3 cells and induce the apoptosis of PC3 cells. The combination of IFN-α with ATRA may enhance these effects on PC3 cells. |
| Keyword | CANCER EXPRESSION INHIBITION RESISTANCE LINES ALPHA All-trans retinoic acid (ATRA) Interferon-alpha (IFN-alpha) Apoptosis Human pancreatic carcinoma cells |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3650997 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/149787 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Wang Xiaohua,Yin Yuanqin,Ma Ping,et al. Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(3):224-228. |
| APA | Wang Xiaohua,Yin Yuanqin,Ma Ping,Sui Chengguang,Meng Fandong,&Jiang Youhong.(2009).Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon.CHINESE JOURNAL OF CANCER RESEARCH,21(3),224-228. |
| MLA | Wang Xiaohua,et al."Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon".CHINESE JOURNAL OF CANCER RESEARCH 21.3(2009):224-228. |
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