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Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon
Alternative TitleApoptosis of Human Pancreatic Carcinoma Cells Induced By All-Trans Retinoic Acid and Interferon
Wang Xiaohua; Yin Yuanqin; Ma Ping; Sui Chengguang; Meng Fandong; Jiang Youhong
2009
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume21Issue:3Pages:224-228
AbstractTo investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-alpha).
Other AbstractObjective: To investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-α). Methods: PC3 cells were treated with ATRA and IFN-α. The inhibitory rate of PC3 cell proliferation was detected using MTT method. Cellular apoptosis was determined with flow cytometry. The percentage of PC3 cell apoptosis was assayed using TUNEL methods. Results: ATRA and IFN-α could inhibit cellular proliferation and induces cellular apoptosis of PC3 cells. The inhibitory effect was stronger when the ATRA and IFN-α were combined as a therapy. Conclusion: ATRA inhibits the proliferation of PC3 cells and induce the apoptosis of PC3 cells. The combination of IFN-α with ATRA may enhance these effects on PC3 cells.
KeywordCANCER EXPRESSION INHIBITION RESISTANCE LINES ALPHA All-trans retinoic acid (ATRA) Interferon-alpha (IFN-alpha) Apoptosis Human pancreatic carcinoma cells
Indexed ByCSCD
Language英语
CSCD IDCSCD:3650997
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149787
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Wang Xiaohua,Yin Yuanqin,Ma Ping,et al. Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(3):224-228.
APA Wang Xiaohua,Yin Yuanqin,Ma Ping,Sui Chengguang,Meng Fandong,&Jiang Youhong.(2009).Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon.CHINESE JOURNAL OF CANCER RESEARCH,21(3),224-228.
MLA Wang Xiaohua,et al."Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon".CHINESE JOURNAL OF CANCER RESEARCH 21.3(2009):224-228.
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