Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon

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	Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon
其他题名	Apoptosis of Human Pancreatic Carcinoma Cells Induced By All-Trans Retinoic Acid and Interferon
	Wang Xiaohua; Yin Yuanqin; Ma Ping; Sui Chengguang; Meng Fandong; Jiang Youhong
	2009
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	21 期号:3 页码:224-228
摘要	To investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-alpha).
其他摘要	Objective: To investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-α). Methods: PC3 cells were treated with ATRA and IFN-α. The inhibitory rate of PC3 cell proliferation was detected using MTT method. Cellular apoptosis was determined with flow cytometry. The percentage of PC3 cell apoptosis was assayed using TUNEL methods. Results: ATRA and IFN-α could inhibit cellular proliferation and induces cellular apoptosis of PC3 cells. The inhibitory effect was stronger when the ATRA and IFN-α were combined as a therapy. Conclusion: ATRA inhibits the proliferation of PC3 cells and induce the apoptosis of PC3 cells. The combination of IFN-α with ATRA may enhance these effects on PC3 cells.
关键词	CANCER EXPRESSION INHIBITION RESISTANCE LINES ALPHA All-trans retinoic acid (ATRA) Interferon-alpha (IFN-alpha) Apoptosis Human pancreatic carcinoma cells
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3650997
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/149787
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Wang Xiaohua,Yin Yuanqin,Ma Ping,et al. Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(3):224-228.
APA	Wang Xiaohua,Yin Yuanqin,Ma Ping,Sui Chengguang,Meng Fandong,&Jiang Youhong.(2009).Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon.CHINESE JOURNAL OF CANCER RESEARCH,21(3),224-228.
MLA	Wang Xiaohua,et al."Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon".CHINESE JOURNAL OF CANCER RESEARCH 21.3(2009):224-228.