Expressions of Livin and Smac proteins in non-small cell lung cancer

IMR OpenIR

	Expressions of Livin and Smac proteins in non-small cell lung cancer
其他题名	Expressions of Livin and Smac proteins in non-small cell lung cancer
	Yang Chunlu 1; Chen Xiao 1; Zhao Jun 1; Lan Xingang 1; Xu Sun 1; Zhang Huan 2; Han Libo 1; Zhang Lin 1
	2008
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	20 期号:2 页码:144-149
摘要	Objective: To investigate the expression characteristics of Livin and second mitochondrial activator of Caspase (Smac) proteins in non-small cell lung cancer (NSCLC), and analyze their effect on patients' prognosis. Methods: The expressions of Livin and Smac proteins were detected in 89 NSCLC tissue samples and 25 normal lung tissue samples by immunohistochemical technique. Results: The positive expression rates of Livin and Smac proteins in NSCLC tissues were 53.9%, and 58.4% respectively, higher than that in normal lung tissues (P 0.05). The expression level of Smac protein was closely related to lymph node metastasis, TNM stage (P 0.05). Kaplan-Meier analysis revealed a significant impact on survival by Livin protein in NSCLC (P 0.05). Conclusions: Overexpression of Livin protein may play a promoting role in the occurrence and progression of NSCLC. Moreover, it may bring an adverse effect on patients' prognosis. Although overexpression of Smac protein affects the occurrence and progression of NSCLC, it has no relationship with the prognosis. Livin protein may be helpful to evaluate the progression of NSCLC, and to predict the prognosis.
其他摘要	Objective:To investigate the expression characteristics of Livin and second mitochondrial activator of Caspase(Smac) proteins in non-small cell lung cancer(NSCLC),and analyze their effect on patients'prognosis.Methods:The expressions of Livin and Smac proteins were detected in 89 NSCLC tissue samples and 25 normal lung tissue samples by immunohistochemical technique.Results:The positive expression rates of Livin and Smac proteins in NSCLC tissues were 53.9%,and 58.4% respectively,higher than that in normal lung tissues(P 0.05).The expression level of Smac protein was closely related to lymph node metastasis,TNM stage(P 0.05).Kaplan-Meier analysis revealed a significant impact on survival by Livin protein in NSCLC (P 0.05).Conclusion:Overexpression of Livin protein may play a promoting role in the occurrence and progression of NSCLC.Moreover,it may bring an adverse effect on patients'prognosis.Although overexpression of Smac protein affects the occurrence and progression of NSCLC,it has no relationship with the prognosis. Livin protein may be helpful to evaluate the progression of NSCLC,and to predict the prognosis.
关键词	ML-IAP APOPTOSIS INHIBITOR FAMILY GENE SURVIVIN MEMBER TARGET non-small cell lung cancer Livin Smac lymph node metastasis prognosis immunohistochemistry
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3299657
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/150340
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.MCH Hosp Tanggu Dist, Ctr Ultrasound, Tianjin 300451, Peoples R China
推荐引用方式 GB/T 7714	Yang Chunlu,Chen Xiao,Zhao Jun,et al. Expressions of Livin and Smac proteins in non-small cell lung cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(2):144-149.
APA	Yang Chunlu.,Chen Xiao.,Zhao Jun.,Lan Xingang.,Xu Sun.,...&Zhang Lin.(2008).Expressions of Livin and Smac proteins in non-small cell lung cancer.CHINESE JOURNAL OF CANCER RESEARCH,20(2),144-149.
MLA	Yang Chunlu,et al."Expressions of Livin and Smac proteins in non-small cell lung cancer".CHINESE JOURNAL OF CANCER RESEARCH 20.2(2008):144-149.