| Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives | |
| Alternative Title | Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives |
| Ren Li; Liu Yang; Yu Guihua; Gao Yuan; Liu Xin; Wang Bo; Deng Xiaonan; Cheng Maosheng | |
| 2014 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 30Issue:4Pages:639-643 |
| Abstract | Eleven novel triterpenoid saponins, N-substituted-beta-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines. |
| Other Abstract | Eleven novel triterpenoid saponins, N-substituted-?-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines. |
| Keyword | TRITERPENOID SAPONINS BEARING ALBIZIA-JULIBRISSIN DISACCHARIDE MOIETY BETA-HEDERIN RAIN-FOREST ANALOGS N-Substituted glucosamine-bearing triterpenoid saponin Tumor cytotoxicity Oleanolic acid |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [PhD Scientific Research Opening Foundation Projects of Liaoning Province of China] |
| CSCD ID | CSCD:5214902 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/150348 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Ren Li,Liu Yang,Yu Guihua,et al. Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(4):639-643. |
| APA | Ren Li.,Liu Yang.,Yu Guihua.,Gao Yuan.,Liu Xin.,...&Cheng Maosheng.(2014).Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(4),639-643. |
| MLA | Ren Li,et al."Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.4(2014):639-643. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment