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Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives
Alternative TitleSynthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives
Ren Li; Liu Yang; Yu Guihua; Gao Yuan; Liu Xin; Wang Bo; Deng Xiaonan; Cheng Maosheng
2014
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume30Issue:4Pages:639-643
AbstractEleven novel triterpenoid saponins, N-substituted-beta-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines.
Other AbstractEleven novel triterpenoid saponins, N-substituted-?-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines.
KeywordTRITERPENOID SAPONINS BEARING ALBIZIA-JULIBRISSIN DISACCHARIDE MOIETY BETA-HEDERIN RAIN-FOREST ANALOGS N-Substituted glucosamine-bearing triterpenoid saponin Tumor cytotoxicity Oleanolic acid
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [PhD Scientific Research Opening Foundation Projects of Liaoning Province of China]
CSCD IDCSCD:5214902
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/150348
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Ren Li,Liu Yang,Yu Guihua,et al. Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(4):639-643.
APA Ren Li.,Liu Yang.,Yu Guihua.,Gao Yuan.,Liu Xin.,...&Cheng Maosheng.(2014).Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(4),639-643.
MLA Ren Li,et al."Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.4(2014):639-643.
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