Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives

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	Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives
其他题名	Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives
	Ren Li; Liu Yang; Yu Guihua; Gao Yuan; Liu Xin; Wang Bo; Deng Xiaonan; Cheng Maosheng
	2014
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	30 期号:4 页码:639-643
摘要	Eleven novel triterpenoid saponins, N-substituted-beta-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines.
其他摘要	Eleven novel triterpenoid saponins, N-substituted-?-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines.
关键词	TRITERPENOID SAPONINS BEARING ALBIZIA-JULIBRISSIN DISACCHARIDE MOIETY BETA-HEDERIN RAIN-FOREST ANALOGS N-Substituted glucosamine-bearing triterpenoid saponin Tumor cytotoxicity Oleanolic acid
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [PhD Scientific Research Opening Foundation Projects of Liaoning Province of China]
CSCD记录号	CSCD:5214902
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/150348
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Ren Li,Liu Yang,Yu Guihua,et al. Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(4):639-643.
APA	Ren Li.,Liu Yang.,Yu Guihua.,Gao Yuan.,Liu Xin.,...&Cheng Maosheng.(2014).Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(4),639-643.
MLA	Ren Li,et al."Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.4(2014):639-643.