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Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial
Alternative TitleEvaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial
Gao Jiandong1; Zhao Yujie1; Xu Chenshi1; Zhao Jing2; Huang Yuguang2; Wang Tianlong4; Pei Ling5; Wang Jian5; Yao Linong6; Ding Qian6; Tan Zhiming7; Zhu Zhirong8; Yue Yun1
2012
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume125Issue:8Pages:1389-1392
AbstractBackground As a new electroencephalogram (EEG) signal processing technique for monitoring the depth of anesthesia, entropy consists of two indices: reaction entropy (RE) and state entropy (SE). Our study compared entropy with classical bispectral index (BIS) in reduction of myoelectrical interference and noxious stimuli with EEG signals.
Other AbstractBackground As a new electroencephalogram (EEG) signal processing technique for monitoring the depth of anesthesia, entropy consists of two indices: reaction entropy (RE) and state entropy (SE). Our study compared entropy with classical bispectral index (BIS) in reduction of myoelectrical interference and noxious stimuli with EEG signals. Methods Two hundred and eighty patients (ASA I–II, 18–60 years old) undergoing scheduled surgeries from seven medical centers were enrolled. Anesthesia induction was managed with propofol via the target-controlled infusion (TCI) system. The results of BIS, RE, SE, mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthesia induction, at the moment of unconsciousness, before and 2 minutes after administration of muscle relaxant, and before and one and three minutes after the tracheal intubation. Results The values of half maximum effective concentrations (EC50), 5% effective concentrations (EC05) and 95% effective concentrations (EC95) of propofol effect-site concentration at the onset of unconsciousness were 1.2 (1.1–1.3 μg/ml), 2.5 (2.4–2.5 μg/ml) and 3.7 (3.7–3.8 μg/ml), while those of the predicted plasma propofol concentration were 2.8 (2.7–2.9 μg/ml), 3.9 (3.8–3.9 μg/ml) and 4.9 (4.8–5.0 μg/ml), respectively. The values of BIS, SE and RE were 62, 59 and 63 when 50% of patients lost consciousness, and 79, 80, 85 and 42, 37, 44, respectively, when 5% and 95% of patients were unconscious. The values of BIS, RE and SE dropped two minutes after the injection of muscle relaxant, but there were no significant differences between RE and SE. MAP and HR increased visibly, which indicated a reaction to tracheal intubation; the values of BIS, RE and SE, however, did not display any significant changes. Conclusions This large-sample multicentric study confirmed the values of RE and SE as approximating BIS value, at the onset of unconsciousness during propofol TCI anesthesia. After elimination of myoelectrical activation, all values of RE, SE and BIS decreased significantly and the three indices were less sensitive to noxious stimuli than cardiovascular responses.
KeywordSPECTRAL ENTROPY NEUROMUSCULAR BLOCK MUSCLE-RELAXANT FREQUENCY PANCURONIUM PERFORMANCE SEVOFLURANE HALOTHANE PROPOFOL VALUES propofol target-controlled infusion unconsciousness bispectral index entropy dose-response relationship
Indexed ByCSCD
Language英语
CSCD IDCSCD:4498353
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/150702
Collection中国科学院金属研究所
Affiliation1.Capital Med University, Beijing Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China
2.Chinese Acad Med Sci, Department Anesthesiol, Beijing 100730, Peoples R China Department Anesthesiol
3.Beijing Union Med Coll Hosp, Beijing 100730, Peoples R China
4.Capital Med University, Xuanwu Hosp, Dept Anesthesiol, Beijing 100053, Peoples R China
5.中国科学院金属研究所
6.中国科学院地球环境研究所
7.复旦大学
8.中国科学院广州地球化学研究所
Recommended Citation
GB/T 7714
Gao Jiandong,Zhao Yujie,Xu Chenshi,et al. Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial[J]. CHINESE MEDICAL JOURNAL,2012,125(8):1389-1392.
APA Gao Jiandong.,Zhao Yujie.,Xu Chenshi.,Zhao Jing.,Huang Yuguang.,...&Yue Yun.(2012).Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial.CHINESE MEDICAL JOURNAL,125(8),1389-1392.
MLA Gao Jiandong,et al."Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial".CHINESE MEDICAL JOURNAL 125.8(2012):1389-1392.
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