Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure

IMR OpenIR

	Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure
其他题名	Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure
	Huang DongHui; Sun Hao; Shi JingPu
	2016
发表期刊	Chinese Medical Journal
ISSN	0366-6999
卷号	129 期号:5 页码:570-577
摘要	Background: Many studies have explored the diagnostic performance of soluble suppression of tumorigenicity-2 (sST2) for heart failure (HF), but the results are inconsistent. Here, we performed a meta-analysis to assess the role of sST2 in the diagnosis of HF. Methods: We searched PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database from inception to April 2015. Studies that investigated the diagnostic role of sST2 for HF were reviewed. The numbers of true-positive, false-positive, false-negative, and true-negative results were extracted to calculate pooled diagnostic odds ratio (DOR) with 95% confidence interval (CI) and the summary receiver operating characteristic curve and area under the curve (AUC). The Spearman correlation coefficient was used to check the threshold effect. The Cochran Q statistic (P 50%) were used to assess the nonthreshold effect. Meta-regression was conducted to explore the source of heterogeneity; subgroup analysis showed the results in different subgroups. Finally, the Deeks' test was performed to assess the publication bias. Results: Nine articles including 10 studies were included in the meta-analysis. The pooled sensitivity was 0.84 (95% CI: 0.81–0.86), and pooled specificity was 0.74 (95% CI: 0.72–0.76). The summary DOR was 8.49 (95% CI: 4.54–15.86), and AUC was 0.81 (standard error: 0.03). The Spearman correlation coefficient identified the nonsignificant threshold effect (coefficient = 0.49, P = 0.148), but the nonthreshold effect heterogeneity was significant (Cochran Q = 58.52, P < 0.0001; I2 = 84.6%). Meta-regression found that characteristics of controls might be the suggestive source of nonthreshold effect heterogeneity (P = 0.095). Subgroup analysis found that DOR was 5.65 and 7.86, respectively for the controls of hospital patients and healthy populations. Deeks' test demonstrated that there was no publication bias (P = 0.616). Conclusion: The meta-analysis illustrated that sST2 might play a role in diagnosing HF.
其他摘要	Background: Many studies have explored the diagnostic performance of soluble suppression of tumorigenicity-2 (sST2) for heart failure (HF), but the results are inconsistent. Here, we performed a meta-analysis to assess the role of sST2 in the diagnosis of HF. Methods: We searched PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database from inception to April 2015. Studies that investigated the diagnostic role of sST2 for HF were reviewed. The numbers of true-positive, false-positive, false-negative, and true-negative results were extracted to calculate pooled diagnostic odds ratio ( DOR ) with 95% confidence interval ( CI ) and the summary receiver operating characteristic curve and area under the curve (AUC). The Spearman correlation coefficient was used to check the threshold effect. The Cochran Q statistic ( P < 0.05) and the inconsistency index ( I 2 > 50%) were used to assess the nonthreshold effect. Meta-regression was conducted to explore the source of heterogeneity; subgroup analysis showed the results in different subgroups. Finally, the Deeks’ test was performed to assess the publication bias. Results: Nine articles including 10 studies were included in the meta-analysis. The pooled sensitivity was 0.84 (95% CI : 0.81–0.86), and pooled specificity was 0.74 (95% CI : 0.72–0.76). The summary DOR was 8.49 (95% CI : 4.54–15.86), and AUC was 0.81 (standard error: 0.03). The Spearman correlation coefficient identified the nonsignificant threshold effect (coefficient = 0.49, P = 0.148), but the nonthreshold effect heterogeneity was significant (Cochran Q = 58.52, P < 0.0001; I 2 = 84.6%). Meta-regression found that characteristics of controls might be the suggestive source of nonthreshold effect heterogeneity ( P = 0.095). Subgroup analysis found that DOR was 5.65 and 7.86, respectively for the controls of hospital patients and healthy populations. Deeks’ test demonstrated that there was no publication bias ( P = 0.616). Conclusion: The meta-analysis illustrated that sST2 might play a role in diagnosing HF.
关键词	Biomarker Medicine R Diagnosis Heart Failure Meta-analysis Soluble Suppression of Tumorigenicity-2
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:5650418
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/150705
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Huang DongHui,Sun Hao,Shi JingPu. Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure[J]. Chinese Medical Journal,2016,129(5):570-577.
APA	Huang DongHui,Sun Hao,&Shi JingPu.(2016).Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure.Chinese Medical Journal,129(5),570-577.
MLA	Huang DongHui,et al."Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure".Chinese Medical Journal 129.5(2016):570-577.