| Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air | |
| Alternative Title | Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air |
| Yin Lu1; Jia Xian1; Li Xing Shu2; Chan Albert S C1 | |
| 2010 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 21Issue:7Pages:774-777 |
| Abstract | Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee). (C) 2010 Xian Jia. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Other Abstract | Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee). |
| Keyword | RACEMIC SECONDARY ALCOHOLS RECOMBINANT ESCHERICHIA-COLI CHIRAL NHC-PD(II) COMPLEXES ALPHA-HYDROXY ESTERS AEROBIC OXIDATION MOLECULAR-OXYGEN SALEN COMPLEXES (R)-O-CHLOROMANDELATE (-)-SPARTEINE MODEL Ambient air Vanadium-catalyzed OKR Methyl o-chloromandelate Schiff base ligands |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Ministry of Education] |
| CSCD ID | CSCD:3924935 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/151116 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.中国科学院广州地球化学研究所 |
| Recommended Citation GB/T 7714 | Yin Lu,Jia Xian,Li Xing Shu,et al. Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air[J]. CHINESE CHEMICAL LETTERS,2010,21(7):774-777. |
| APA | Yin Lu,Jia Xian,Li Xing Shu,&Chan Albert S C.(2010).Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air.CHINESE CHEMICAL LETTERS,21(7),774-777. |
| MLA | Yin Lu,et al."Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air".CHINESE CHEMICAL LETTERS 21.7(2010):774-777. |
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