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Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air
Alternative TitleSimply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air
Yin Lu1; Jia Xian1; Li Xing Shu2; Chan Albert S C1
2010
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume21Issue:7Pages:774-777
AbstractVanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee). (C) 2010 Xian Jia. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractVanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee).
KeywordRACEMIC SECONDARY ALCOHOLS RECOMBINANT ESCHERICHIA-COLI CHIRAL NHC-PD(II) COMPLEXES ALPHA-HYDROXY ESTERS AEROBIC OXIDATION MOLECULAR-OXYGEN SALEN COMPLEXES (R)-O-CHLOROMANDELATE (-)-SPARTEINE MODEL Ambient air Vanadium-catalyzed OKR Methyl o-chloromandelate Schiff base ligands
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Ministry of Education]
CSCD IDCSCD:3924935
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151116
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.中国科学院广州地球化学研究所
Recommended Citation
GB/T 7714
Yin Lu,Jia Xian,Li Xing Shu,et al. Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air[J]. CHINESE CHEMICAL LETTERS,2010,21(7):774-777.
APA Yin Lu,Jia Xian,Li Xing Shu,&Chan Albert S C.(2010).Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air.CHINESE CHEMICAL LETTERS,21(7),774-777.
MLA Yin Lu,et al."Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air".CHINESE CHEMICAL LETTERS 21.7(2010):774-777.
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