Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air

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	Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air
其他题名	Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air
	Yin Lu 1; Jia Xian 1; Li Xing Shu 2; Chan Albert S C 1
	2010
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	21 期号:7 页码:774-777
摘要	Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee). (C) 2010 Xian Jia. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee).
关键词	RACEMIC SECONDARY ALCOHOLS RECOMBINANT ESCHERICHIA-COLI CHIRAL NHC-PD(II) COMPLEXES ALPHA-HYDROXY ESTERS AEROBIC OXIDATION MOLECULAR-OXYGEN SALEN COMPLEXES (R)-O-CHLOROMANDELATE (-)-SPARTEINE MODEL Ambient air Vanadium-catalyzed OKR Methyl o-chloromandelate Schiff base ligands
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Ministry of Education]
CSCD记录号	CSCD:3924935
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151116
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院广州地球化学研究所
推荐引用方式 GB/T 7714	Yin Lu,Jia Xian,Li Xing Shu,et al. Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air[J]. CHINESE CHEMICAL LETTERS,2010,21(7):774-777.
APA	Yin Lu,Jia Xian,Li Xing Shu,&Chan Albert S C.(2010).Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air.CHINESE CHEMICAL LETTERS,21(7),774-777.
MLA	Yin Lu,et al."Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air".CHINESE CHEMICAL LETTERS 21.7(2010):774-777.