| Temporal effect of local hyperthermia on murine contact hypersensitivity | |
| Alternative Title | Temporal effect of local hyperthermia on murine contact hypersensitivity |
| Zhang Lan1; Wang Yiru2; Hong Yuxiao1; Xu Yaqin1; Zhang Li1; Li Xiaodong1; Xiao Ting1; Lu Dongqing2; Chen Hongduo1; Gao Xinghua1 | |
| 2013 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 126Issue:8Pages:1555-1559 |
| Abstract | Background The sensitization and elicitation phases are involved in the immunopathogenesis of contact hypersensitivity (CHS). Langerhans cells (LCs) are believed to play pivotal roles in the sensitization stage of CHS. Local hyperthermia on skin induces the migration as well as maturation of epidermal LCs. Although fever-range whole body hyperthermia and local hyperthermia at 43 degrees C prior to sensitization were reported to suppress CHS, the effects of different temperatures and the timing sequence of local hyperthermia on CHS have not been tackled. |
| Other Abstract | Background The sensitization and elicitation phases are involved in the immunopathogenesis of contact hypersensitivity (CHS). Langerhans cells (LCs) are believed to play pivotal roles in the sensitization stage of CHS. Local hyperthermia on skin induces the migration as well as maturation of epidermal LCs. Although fever-range whole body hyperthermia and local hyperthermia at 43°C prior to sensitization were reported to suppress CHS, the effects of different temperatures and the timing sequence of local hyperthermia on CHS have not been tackled. Methods Local hyperthermia was applied to murine dorsal skin 3 days prior to, concurrent with, or 2 days post sensitization with fluorescein isothiocyanate (FITC) in BALB/c mice. Local hyperthermia temperatures at 37°C, 39°C, 41°C and 43°C were applied to mouse dorsal skin and the severity of CHS was calculated by measuring the swelling response of the challenged ears. Results Local hyperthermia at 39°C, 41°C and 43°C prior to sensitization reduced the severity of CHS, as compared with that at 37°C. The suppression of CHS was temperature dependant in that higher temperature had a stronger effect. On the contrary, the hyperthermia treatments, either concurrent with or post-sensitization, resulted in an enhanced temperature-dependant ear swelling response. Conclusions The severity of murine CHS could be influenced by local hyperthermia at the sensitization stage in a temperature dependant manner. The temporal effect of local hyperthermia suggested a novel factor in interpreting the severity of allergic contact dermatitis. |
| Keyword | LANGERHANS CELLS SKIN DERMATITIS MIGRATION MICE MATURATION TOLERANCE APOPTOSIS RESPONSES fever dermatitis contact Langerhans cells immunization |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Innovative Research Teams in Universities, Ministry of Education] ; [Liaoning Bureau] |
| CSCD ID | CSCD:4808214 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/151367 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Sun Yat Sen University, Dept Dermatol, Affiliated Hosp 5, Zhuhai 519000, Guangdong, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang Lan,Wang Yiru,Hong Yuxiao,et al. Temporal effect of local hyperthermia on murine contact hypersensitivity[J]. CHINESE MEDICAL JOURNAL,2013,126(8):1555-1559. |
| APA | Zhang Lan.,Wang Yiru.,Hong Yuxiao.,Xu Yaqin.,Zhang Li.,...&Gao Xinghua.(2013).Temporal effect of local hyperthermia on murine contact hypersensitivity.CHINESE MEDICAL JOURNAL,126(8),1555-1559. |
| MLA | Zhang Lan,et al."Temporal effect of local hyperthermia on murine contact hypersensitivity".CHINESE MEDICAL JOURNAL 126.8(2013):1555-1559. |
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