Temporal effect of local hyperthermia on murine contact hypersensitivity

IMR OpenIR

	Temporal effect of local hyperthermia on murine contact hypersensitivity
其他题名	Temporal effect of local hyperthermia on murine contact hypersensitivity
	Zhang Lan 1; Wang Yiru 2; Hong Yuxiao 1; Xu Yaqin 1; Zhang Li 1; Li Xiaodong 1; Xiao Ting 1; Lu Dongqing 2; Chen Hongduo 1; Gao Xinghua 1
	2013
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	126 期号:8 页码:1555-1559
摘要	Background The sensitization and elicitation phases are involved in the immunopathogenesis of contact hypersensitivity (CHS). Langerhans cells (LCs) are believed to play pivotal roles in the sensitization stage of CHS. Local hyperthermia on skin induces the migration as well as maturation of epidermal LCs. Although fever-range whole body hyperthermia and local hyperthermia at 43 degrees C prior to sensitization were reported to suppress CHS, the effects of different temperatures and the timing sequence of local hyperthermia on CHS have not been tackled.
其他摘要	Background The sensitization and elicitation phases are involved in the immunopathogenesis of contact hypersensitivity (CHS). Langerhans cells (LCs) are believed to play pivotal roles in the sensitization stage of CHS. Local hyperthermia on skin induces the migration as well as maturation of epidermal LCs. Although fever-range whole body hyperthermia and local hyperthermia at 43°C prior to sensitization were reported to suppress CHS, the effects of different temperatures and the timing sequence of local hyperthermia on CHS have not been tackled. Methods Local hyperthermia was applied to murine dorsal skin 3 days prior to, concurrent with, or 2 days post sensitization with fluorescein isothiocyanate (FITC) in BALB/c mice. Local hyperthermia temperatures at 37°C, 39°C, 41°C and 43°C were applied to mouse dorsal skin and the severity of CHS was calculated by measuring the swelling response of the challenged ears. Results Local hyperthermia at 39°C, 41°C and 43°C prior to sensitization reduced the severity of CHS, as compared with that at 37°C. The suppression of CHS was temperature dependant in that higher temperature had a stronger effect. On the contrary, the hyperthermia treatments, either concurrent with or post-sensitization, resulted in an enhanced temperature-dependant ear swelling response. Conclusions The severity of murine CHS could be influenced by local hyperthermia at the sensitization stage in a temperature dependant manner. The temporal effect of local hyperthermia suggested a novel factor in interpreting the severity of allergic contact dermatitis.
关键词	LANGERHANS CELLS SKIN DERMATITIS MIGRATION MICE MATURATION TOLERANCE APOPTOSIS RESPONSES fever dermatitis contact Langerhans cells immunization
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Innovative Research Teams in Universities, Ministry of Education] ; [Liaoning Bureau]
CSCD记录号	CSCD:4808214
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151370
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Sun Yat Sen University, Dept Dermatol, Affiliated Hosp 5, Zhuhai 519000, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhang Lan,Wang Yiru,Hong Yuxiao,et al. Temporal effect of local hyperthermia on murine contact hypersensitivity[J]. CHINESE MEDICAL JOURNAL,2013,126(8):1555-1559.
APA	Zhang Lan.,Wang Yiru.,Hong Yuxiao.,Xu Yaqin.,Zhang Li.,...&Gao Xinghua.(2013).Temporal effect of local hyperthermia on murine contact hypersensitivity.CHINESE MEDICAL JOURNAL,126(8),1555-1559.
MLA	Zhang Lan,et al."Temporal effect of local hyperthermia on murine contact hypersensitivity".CHINESE MEDICAL JOURNAL 126.8(2013):1555-1559.