Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome

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	Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome
其他题名	Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome
	Zhang YX 1; Guo XK 1; Wu C 1; Bi B 1; Ren SX 1; Wu CF 1; Zhao GP 1
	2004
发表期刊	CELL RESEARCH
ISSN	1001-0602
卷号	14 期号:3 页码:208-216
摘要	Comparative genomic analysis of the coding sequences (CDSs) of Leptospira interrogans revealed a pair of closely linked genes homologous to the vapBC loci of many other bacteria with respect to both deduced amino acid sequences and operon organizations. Expression of single vapC gene in Escherichia coli resulted in inhibition of bacterial growth, whereas co-expression of vapBC restored the growth effectively. This phenotype is typical for three other characterized toxin-antitoxin systems of bacteria, i.e., mazEFl
其他摘要	Comparative genomic analysis of the coding sequences (CDSs) of Leptospira interrogans revealed a pair of closely linked genes homologous to the vapBC loci of many other bacteria with respect to both deduced amino acid sequences and operon organizations. Expression of single vapC gene in Escherichia coli resulted in inhibition of bacterial growth,whereas co-expression of vapBC restored the growth effectively. This phenotype is typical for three other characterized toxin-antitoxin systems of bacteria, i.e., mazEF1
关键词	STABILITY SYSTEM PLASMID R1 CELL-DEATH PARD GENE REPLICATION COMPLEX IDENTIFICATION RECOMBINATION MAINTENANCE Leptospria toxin-antitoxin system VapBC co-evolution speciation
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:1843650
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151412
专题	中国科学院金属研究所
作者单位	1.中国科学院 2.中国科学院金属研究所 3.Shanghai Med University 2 4.中国科学院青岛生物能源与过程研究所
推荐引用方式 GB/T 7714	Zhang YX,Guo XK,Wu C,et al. Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome[J]. CELL RESEARCH,2004,14(3):208-216.
APA	Zhang YX.,Guo XK.,Wu C.,Bi B.,Ren SX.,...&Zhao GP.(2004).Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome.CELL RESEARCH,14(3),208-216.
MLA	Zhang YX,et al."Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome".CELL RESEARCH 14.3(2004):208-216.