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A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population
Alternative TitleA Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population
Cui Hua1; Li Xiaoying1; Gao Xuewen2; Lu Xiang3; Wu Xiuping4; Wang Xiaofei5; Zheng Xiangqing6; Huang Kui7; Liu Feng8; Luo Zhi9; Yuan Huishu10; Sun Gang11; Kong Jian12; Du Xiaohong13; Zheng Jin1; Liu Hongying14; Zhang Wenju15
2019
Source PublicationCHINESE JOURNAL OF INTEGRATIVE MEDICINE
ISSN1672-0415
Volume25Issue:10Pages:728-735
AbstractObjective To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris (UAP). Methods A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group (160 patients) and a control group (158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), as well as major adverse cardiovascular events (MACEs). Safety was assessed according to adverse events and serious adverse events. Results Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angina attacks (2.92 vs . 4.08, P=0.025), the biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks (P<0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group (P<0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP. ClinicalTrials.gov identifier: NCT03037047
Other AbstractObjective: To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris (UAP). Methods: A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group (160 patients) and a control group (158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), as well as major adverse cardiovascular events (MACEs). Safety was assessed according to adverse events and serious adverse events. Results: Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angina attacks (2.92 vs . 4.08, P =0.025), the biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks (P<0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group (P<0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions: Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP.
KeywordACUTE CORONARY SYNDROME ASSOCIATION TASK-FORCE AMERICAN-COLLEGE DEPSIDE SALTS MILTIORRHIZA QUESTIONNAIRE INTERVENTION GUIDELINES MANAGEMENT ADULTS Salvianolate unstable angina pectoris elderly efficacy
Indexed ByCSCD
Language英语
Funding Project[Science and Technology Commission of Shanghai Municipality]
CSCD IDCSCD:6573721
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151501
Collection中国科学院金属研究所
Affiliation1.Gen Hosp Peoples Liberat Army, Department Geriatr Cardiol, Beijing 100853, Peoples R China
2.Inner Mongolia Peoples Hosp, Department Geriatr Clin, Hohhot 010017, Peoples R China
3.中国科学院南京地理与湖泊研究所
4.Harbin Med University, Dept Cadres Ward 2, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
5.Tianjin First Cent Hosp, Department Cadre Hlth Care, Tianjin 300192, Peoples R China
6.Chongqing Gen Hosp, Department Cardiovasc Med, Chongqing 400013, Peoples R China
7.中国科学院金属研究所
8.中国科学院广州地球化学研究所
9.Beijing Geriatr Hosp, Department Cardiol, Beijing 100095, Peoples R China
10.黑龙江大学
11.Guizhou Prov Hosp Tradit Chinese Med, Department Cardiol, Guiyang 550001, Guizhou, Peoples R China Department Cardiol
12.吉林大学
13.Wenzhou Med University, Dept Cadre Hlth Care, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China
14.Shanghai Green Valley Pharmaceut Co Ltd, Med Department, Shanghai 201203, Peoples R China
15.China Hlth Promot Fdn, Beijing 100161, Peoples R China
Recommended Citation
GB/T 7714
Cui Hua,Li Xiaoying,Gao Xuewen,et al. A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2019,25(10):728-735.
APA Cui Hua.,Li Xiaoying.,Gao Xuewen.,Lu Xiang.,Wu Xiuping.,...&Zhang Wenju.(2019).A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,25(10),728-735.
MLA Cui Hua,et al."A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 25.10(2019):728-735.
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