A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population

IMR OpenIR

	A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population
其他题名	A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population
	Cui Hua 1; Li Xiaoying 1; Gao Xuewen 2; Lu Xiang 3; Wu Xiuping 4; Wang Xiaofei 5; Zheng Xiangqing 6; Huang Kui 7; Liu Feng 8; Luo Zhi 9; Yuan Huishu 10; Sun Gang 11; Kong Jian 12; Du Xiaohong 13; Zheng Jin 1; Liu Hongying 14; Zhang Wenju 15
	2019
发表期刊	CHINESE JOURNAL OF INTEGRATIVE MEDICINE
ISSN	1672-0415
卷号	25 期号:10 页码:728-735
摘要	Objective To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris (UAP). Methods A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group (160 patients) and a control group (158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), as well as major adverse cardiovascular events (MACEs). Safety was assessed according to adverse events and serious adverse events. Results Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angina attacks (2.92 vs . 4.08, P=0.025), the biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks (P<0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group (P<0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP. ClinicalTrials.gov identifier: NCT03037047
其他摘要	Objective: To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris (UAP). Methods: A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group (160 patients) and a control group (158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), as well as major adverse cardiovascular events (MACEs). Safety was assessed according to adverse events and serious adverse events. Results: Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angina attacks (2.92 vs . 4.08, P =0.025), the biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks (P<0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group (P<0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions: Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP.
关键词	ACUTE CORONARY SYNDROME ASSOCIATION TASK-FORCE AMERICAN-COLLEGE DEPSIDE SALTS MILTIORRHIZA QUESTIONNAIRE INTERVENTION GUIDELINES MANAGEMENT ADULTS Salvianolate unstable angina pectoris elderly efficacy
收录类别	CSCD
语种	英语
资助项目	[Science and Technology Commission of Shanghai Municipality]
CSCD记录号	CSCD:6573721
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151504
专题	中国科学院金属研究所
作者单位	1.Gen Hosp Peoples Liberat Army, Department Geriatr Cardiol, Beijing 100853, Peoples R China 2.Inner Mongolia Peoples Hosp, Department Geriatr Clin, Hohhot 010017, Peoples R China 3.中国科学院南京地理与湖泊研究所 4.Harbin Med University, Dept Cadres Ward 2, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China 5.Tianjin First Cent Hosp, Department Cadre Hlth Care, Tianjin 300192, Peoples R China 6.Chongqing Gen Hosp, Department Cardiovasc Med, Chongqing 400013, Peoples R China 7.中国科学院金属研究所 8.中国科学院广州地球化学研究所 9.Beijing Geriatr Hosp, Department Cardiol, Beijing 100095, Peoples R China 10.黑龙江大学 11.Guizhou Prov Hosp Tradit Chinese Med, Department Cardiol, Guiyang 550001, Guizhou, Peoples R China Department Cardiol 12.吉林大学 13.Wenzhou Med University, Dept Cadre Hlth Care, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China 14.Shanghai Green Valley Pharmaceut Co Ltd, Med Department, Shanghai 201203, Peoples R China 15.China Hlth Promot Fdn, Beijing 100161, Peoples R China
推荐引用方式 GB/T 7714	Cui Hua,Li Xiaoying,Gao Xuewen,et al. A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2019,25(10):728-735.
APA	Cui Hua.,Li Xiaoying.,Gao Xuewen.,Lu Xiang.,Wu Xiuping.,...&Zhang Wenju.(2019).A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,25(10),728-735.
MLA	Cui Hua,et al."A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 25.10(2019):728-735.