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Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents
Alternative TitleSynthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents
Meng Ying1; Wang Guan2; Li Yue1; Hou Kuan1; Yuan Yue1; Zhang LiJuan1; Song HongRui1; Shi Wei2
2013
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume24Issue:7Pages:619-621
AbstractA series of pyrrolo1,2-apyrazinone compounds (5a-9f) were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MU method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed. (C) 2013 Hong-Rui Song and Wei Shi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA series of pyrrolo1,2-apyrazinone compounds(5a-9f) were synthesized,and their cytotoxic activity against SKOV-3,A549.HeLa cells in vitro were evaluated by the MTT method.Some of the compounds showed potential antitumor activity against three tumor cell lines.Among them,compounds 9c and 9d showed the most potent cytotoxic activity.The preliminary mechanism of action was discussed
KeywordPyrrolopyrazinone Antitumor Synthesis
Indexed ByCSCD
Language英语
CSCD IDCSCD:4904853
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151511
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.吉林大学
Recommended Citation
GB/T 7714
Meng Ying,Wang Guan,Li Yue,et al. Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents[J]. CHINESE CHEMICAL LETTERS,2013,24(7):619-621.
APA Meng Ying.,Wang Guan.,Li Yue.,Hou Kuan.,Yuan Yue.,...&Shi Wei.(2013).Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents.CHINESE CHEMICAL LETTERS,24(7),619-621.
MLA Meng Ying,et al."Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents".CHINESE CHEMICAL LETTERS 24.7(2013):619-621.
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