Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

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	Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents
其他题名	Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents
	Meng Ying 1; Wang Guan 2; Li Yue 1; Hou Kuan 1; Yuan Yue 1; Zhang LiJuan 1; Song HongRui 1; Shi Wei 2
	2013
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	24 期号:7 页码:619-621
摘要	A series of pyrrolo1,2-apyrazinone compounds (5a-9f) were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MU method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed. (C) 2013 Hong-Rui Song and Wei Shi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A series of pyrrolo1,2-apyrazinone compounds(5a-9f) were synthesized,and their cytotoxic activity against SKOV-3,A549.HeLa cells in vitro were evaluated by the MTT method.Some of the compounds showed potential antitumor activity against three tumor cell lines.Among them,compounds 9c and 9d showed the most potent cytotoxic activity.The preliminary mechanism of action was discussed
关键词	Pyrrolopyrazinone Antitumor Synthesis
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4904853
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151511
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.吉林大学
推荐引用方式 GB/T 7714	Meng Ying,Wang Guan,Li Yue,et al. Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents[J]. CHINESE CHEMICAL LETTERS,2013,24(7):619-621.
APA	Meng Ying.,Wang Guan.,Li Yue.,Hou Kuan.,Yuan Yue.,...&Shi Wei.(2013).Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents.CHINESE CHEMICAL LETTERS,24(7),619-621.
MLA	Meng Ying,et al."Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents".CHINESE CHEMICAL LETTERS 24.7(2013):619-621.