| Role of RECK methylation in gastric cancer and its clinical significance | |
| Alternative Title | Role of RECK methylation in gastric cancer and its clinical significance |
| Du YunYi; Dai DongQiu; Yang Zhi | |
| 2010 | |
| Source Publication | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| ISSN | 1007-9327 |
| Volume | 16Issue:7Pages:904-908 |
| Abstract | AIM: To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric cancer. |
| Other Abstract | AIM: To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric cancer.METHODS: Methylation of RECK gene in 40 paired samples of gastric cancer and its corresponding adjacent normal mucosa, lymph nodes and peritoneal irrigation fluid was detected by methylation-specific polymerase chain reaction.RESULTS: Aberrant methylation of RECK gene was detected in 27.5% (11/40) of the adjacent normal mucosa samples, in 47.5% (19/40) of gastric cancer samples, in 57.1% (12/21) of the lymph node samples,and in 35% (14/40) of peritoneal irrigation fluid samples,respectively, with a significant difference between the adjacent normal mucosa and lymph node samples ( P=0.023). Presence of RECK methylation in the primary tumor samples was significantly correlated with tumor invasion ( P=0.023). The accuracy of RECK methylation in peritoneal lavage fluid samples for the diagnosis of peritoneal metastasis of gastric cancer was 72.5% (26/40), with a sensitivity of 66.7% (6/9) and a specificity of 74.2% (23/31).CONCLUSION: Aberrant methylation of RECK gene may provide useful information for the early diagnosis and treatment of peritoneal metastasis of gastric cancer. |
| Keyword | CYSTEINE-RICH PROTEIN METASTASIS SUPPRESSOR RECK KAZAL MOTIFS RECK COLORECTAL-CANCER PROMOTER HYPERMETHYLATION PERITONEAL-LAVAGE DOWN-REGULATION CELL-LINES GENE EXPRESSION RECK gene Hypermethylation Gastric cancer Metastasis Peritoneal lavage fluid |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Foundation of Education Bureau of Liaoning Province, China] |
| CSCD ID | CSCD:3821205 |
| Citation statistics |
Cited Times:5[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/151516 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Du YunYi,Dai DongQiu,Yang Zhi. Role of RECK methylation in gastric cancer and its clinical significance[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(7):904-908. |
| APA | Du YunYi,Dai DongQiu,&Yang Zhi.(2010).Role of RECK methylation in gastric cancer and its clinical significance.WORLD JOURNAL OF GASTROENTEROLOGY,16(7),904-908. |
| MLA | Du YunYi,et al."Role of RECK methylation in gastric cancer and its clinical significance".WORLD JOURNAL OF GASTROENTEROLOGY 16.7(2010):904-908. |
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