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Role of RECK methylation in gastric cancer and its clinical significance
Alternative TitleRole of RECK methylation in gastric cancer and its clinical significance
Du YunYi; Dai DongQiu; Yang Zhi
2010
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume16Issue:7Pages:904-908
AbstractAIM: To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric cancer.
Other AbstractAIM: To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric cancer.METHODS: Methylation of RECK gene in 40 paired samples of gastric cancer and its corresponding adjacent normal mucosa, lymph nodes and peritoneal irrigation fluid was detected by methylation-specific polymerase chain reaction.RESULTS: Aberrant methylation of RECK gene was detected in 27.5% (11/40) of the adjacent normal mucosa samples, in 47.5% (19/40) of gastric cancer samples, in 57.1% (12/21) of the lymph node samples,and in 35% (14/40) of peritoneal irrigation fluid samples,respectively, with a significant difference between the adjacent normal mucosa and lymph node samples ( P=0.023). Presence of RECK methylation in the primary tumor samples was significantly correlated with tumor invasion ( P=0.023). The accuracy of RECK methylation in peritoneal lavage fluid samples for the diagnosis of peritoneal metastasis of gastric cancer was 72.5% (26/40), with a sensitivity of 66.7% (6/9) and a specificity of 74.2% (23/31).CONCLUSION: Aberrant methylation of RECK gene may provide useful information for the early diagnosis and treatment of peritoneal metastasis of gastric cancer.
KeywordCYSTEINE-RICH PROTEIN METASTASIS SUPPRESSOR RECK KAZAL MOTIFS RECK COLORECTAL-CANCER PROMOTER HYPERMETHYLATION PERITONEAL-LAVAGE DOWN-REGULATION CELL-LINES GENE EXPRESSION RECK gene Hypermethylation Gastric cancer Metastasis Peritoneal lavage fluid
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Foundation of Education Bureau of Liaoning Province, China]
CSCD IDCSCD:3821205
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Cited Times:4[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151518
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Du YunYi,Dai DongQiu,Yang Zhi. Role of RECK methylation in gastric cancer and its clinical significance[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(7):904-908.
APA Du YunYi,Dai DongQiu,&Yang Zhi.(2010).Role of RECK methylation in gastric cancer and its clinical significance.WORLD JOURNAL OF GASTROENTEROLOGY,16(7),904-908.
MLA Du YunYi,et al."Role of RECK methylation in gastric cancer and its clinical significance".WORLD JOURNAL OF GASTROENTEROLOGY 16.7(2010):904-908.
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