Role of RECK methylation in gastric cancer and its clinical significance

IMR OpenIR

	Role of RECK methylation in gastric cancer and its clinical significance
其他题名	Role of RECK methylation in gastric cancer and its clinical significance
	Du YunYi; Dai DongQiu; Yang Zhi
	2010
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
卷号	16 期号:7 页码:904-908
摘要	AIM: To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric cancer.
其他摘要	AIM: To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric cancer.METHODS: Methylation of RECK gene in 40 paired samples of gastric cancer and its corresponding adjacent normal mucosa, lymph nodes and peritoneal irrigation fluid was detected by methylation-specific polymerase chain reaction.RESULTS: Aberrant methylation of RECK gene was detected in 27.5% (11/40) of the adjacent normal mucosa samples, in 47.5% (19/40) of gastric cancer samples, in 57.1% (12/21) of the lymph node samples,and in 35% (14/40) of peritoneal irrigation fluid samples,respectively, with a significant difference between the adjacent normal mucosa and lymph node samples ( P=0.023). Presence of RECK methylation in the primary tumor samples was significantly correlated with tumor invasion ( P=0.023). The accuracy of RECK methylation in peritoneal lavage fluid samples for the diagnosis of peritoneal metastasis of gastric cancer was 72.5% (26/40), with a sensitivity of 66.7% (6/9) and a specificity of 74.2% (23/31).CONCLUSION: Aberrant methylation of RECK gene may provide useful information for the early diagnosis and treatment of peritoneal metastasis of gastric cancer.
关键词	CYSTEINE-RICH PROTEIN METASTASIS SUPPRESSOR RECK KAZAL MOTIFS RECK COLORECTAL-CANCER PROMOTER HYPERMETHYLATION PERITONEAL-LAVAGE DOWN-REGULATION CELL-LINES GENE EXPRESSION RECK gene Hypermethylation Gastric cancer Metastasis Peritoneal lavage fluid
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Foundation of Education Bureau of Liaoning Province, China]
CSCD记录号	CSCD:3821205
引用统计	被引频次：5[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151518
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Du YunYi,Dai DongQiu,Yang Zhi. Role of RECK methylation in gastric cancer and its clinical significance[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(7):904-908.
APA	Du YunYi,Dai DongQiu,&Yang Zhi.(2010).Role of RECK methylation in gastric cancer and its clinical significance.WORLD JOURNAL OF GASTROENTEROLOGY,16(7),904-908.
MLA	Du YunYi,et al."Role of RECK methylation in gastric cancer and its clinical significance".WORLD JOURNAL OF GASTROENTEROLOGY 16.7(2010):904-908.