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Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists
Alternative TitleDesign, synthesis and biological evaluation of 1,4-dihydrothieno3′,2′:5,6thiopyrano4,3- cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists
Sun Rui1; Song Jing1; Liu Si Jie1; Zhao Hui1; Yan Chun Li1; Zhang Ai Jun1; Koirala Diwa3; Li Da Wei3; Hu Chun1
2011
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume22Issue:3Pages:256-259
AbstractThe estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women, osteoporosis, reproductive cancers such as breast cancer, uterine cancer and prostate cancer. 1,4-Dihydrothieno3',2':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives were designed, synthesized and biological evaluated as potential estrogen receptor antagonists. (C) 2010 Chun Hu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractThe estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women, osteoporosis, reproductive cancers such as breast cancer, uterine cancer and prostate cancer. 1,4-Dihydrothieno3',2':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives were designed, synthesized and biological evaluated as potential estrogen receptor antagonists
KeywordBETA Estrogen receptor antagonists Synthesis Biological activity Thiophene Pyrazole Thiopyran Piperazine
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China (NSFC)]
CSCD IDCSCD:4149926
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151614
Collection中国科学院金属研究所
Affiliation1.上海市地震局
2.中国科学院金属研究所
3.上海交通大学
Recommended Citation
GB/T 7714
Sun Rui,Song Jing,Liu Si Jie,et al. Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists[J]. CHINESE CHEMICAL LETTERS,2011,22(3):256-259.
APA Sun Rui.,Song Jing.,Liu Si Jie.,Zhao Hui.,Yan Chun Li.,...&Hu Chun.(2011).Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists.CHINESE CHEMICAL LETTERS,22(3),256-259.
MLA Sun Rui,et al."Design, synthesis and biological evaluation of 1,4-dihydrothieno3 ',2 ':5,6thiopyrano4,3-cpyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists".CHINESE CHEMICAL LETTERS 22.3(2011):256-259.
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