Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats

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	Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats
其他题名	Sleeve gastrectomy prevents lipoprotein receptor-1expression in aortas of obese rats
	Bai Jie; Wang Yong; Liu Yuan; Geng DongHua; Liu JinGang
	2011
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
卷号	17 期号:32 页码:3739-3744
摘要	AIM: To investigate the effects of sleeve gastrectomy on adipose tissue infiltration and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression in rat aortas.
其他摘要	AIM:To investigate the effects of sleeve gastrectomy on adipose tissue infiltration and lectin-like oxidized low density lipoprotein receptor-1(LOX-1)expression in rat aortas. METHODS:Twenty-four rats were randomized into three groups:normal chow(control),high fat diet(HD) and high fat diet with sleeve gastrectomy(SG).After surgery,the HD and SG groups were fed a high fat diet.Animals were sacrificed and plasma high density lipoprotein(HDL)and low density lipoprotein(LDL)levels were determined.LOX-1 protein and LOX-1 mRNA expression was also measured.Aortas were stained with Nile red to visualize adipose tissue. RESULT:Body weights were higher in the HD group compared to the other groups.HDL levels in control, HD,and SG groups were 32.9±6.2 mg/dL,43.4±4.0 mg/dL and 37.5±4.3 mg/dL,respectively.LDL levels in control,HD,and SG groups were 31.8±4.5 mg/dL, 53.3±5.1 mg/dL and 40.5±3.7 mg/dL,respectively. LOX-1 protein and LOX-1 mRNA expression was greater in the HD group versus the other groups.Staining for adipose tissue in aortas was greater in the HD group in comparison to the other groups.Thus,a high fat diet elevates LOX-1 protein and mRNA expression in aorta. CONCLUSION:Sleeve gastrectomy decreases plasma LDL levels,and downregulates LOX-1 protein and mRNA expression.
关键词	LOW-DENSITY-LIPOPROTEIN OXIDIZED LDL RECEPTOR-1 VASCULAR ENDOTHELIAL-CELLS WEIGHT-LOSS BLOOD-PRESSURE GASTRIC BYPASS LONG-TERM HYPERTENSION LOX-1 WOMEN Sleeve gastrectomy Morbid obesity High fat diet Aorta Lipoprotein receptor-1 expression
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Special Fund for Technology of Liaoning Province]
CSCD记录号	CSCD:4334543
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151701
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Bai Jie,Wang Yong,Liu Yuan,et al. Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(32):3739-3744.
APA	Bai Jie,Wang Yong,Liu Yuan,Geng DongHua,&Liu JinGang.(2011).Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats.WORLD JOURNAL OF GASTROENTEROLOGY,17(32),3739-3744.
MLA	Bai Jie,et al."Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats".WORLD JOURNAL OF GASTROENTEROLOGY 17.32(2011):3739-3744.