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Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats
Alternative TitleSleeve gastrectomy prevents lipoprotein receptor-1expression in aortas of obese rats
Bai Jie; Wang Yong; Liu Yuan; Geng DongHua; Liu JinGang
2011
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume17Issue:32Pages:3739-3744
AbstractAIM: To investigate the effects of sleeve gastrectomy on adipose tissue infiltration and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression in rat aortas.
Other AbstractAIM:To investigate the effects of sleeve gastrectomy on adipose tissue infiltration and lectin-like oxidized low density lipoprotein receptor-1(LOX-1)expression in rat aortas. METHODS:Twenty-four rats were randomized into three groups:normal chow(control),high fat diet(HD) and high fat diet with sleeve gastrectomy(SG).After surgery,the HD and SG groups were fed a high fat diet.Animals were sacrificed and plasma high density lipoprotein(HDL)and low density lipoprotein(LDL)levels were determined.LOX-1 protein and LOX-1 mRNA expression was also measured.Aortas were stained with Nile red to visualize adipose tissue. RESULT:Body weights were higher in the HD group compared to the other groups.HDL levels in control, HD,and SG groups were 32.9±6.2 mg/dL,43.4±4.0 mg/dL and 37.5±4.3 mg/dL,respectively.LDL levels in control,HD,and SG groups were 31.8±4.5 mg/dL, 53.3±5.1 mg/dL and 40.5±3.7 mg/dL,respectively. LOX-1 protein and LOX-1 mRNA expression was greater in the HD group versus the other groups.Staining for adipose tissue in aortas was greater in the HD group in comparison to the other groups.Thus,a high fat diet elevates LOX-1 protein and mRNA expression in aorta. CONCLUSION:Sleeve gastrectomy decreases plasma LDL levels,and downregulates LOX-1 protein and mRNA expression.
KeywordLOW-DENSITY-LIPOPROTEIN OXIDIZED LDL RECEPTOR-1 VASCULAR ENDOTHELIAL-CELLS WEIGHT-LOSS BLOOD-PRESSURE GASTRIC BYPASS LONG-TERM HYPERTENSION LOX-1 WOMEN Sleeve gastrectomy Morbid obesity High fat diet Aorta Lipoprotein receptor-1 expression
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Special Fund for Technology of Liaoning Province]
CSCD IDCSCD:4334543
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151701
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Bai Jie,Wang Yong,Liu Yuan,et al. Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(32):3739-3744.
APA Bai Jie,Wang Yong,Liu Yuan,Geng DongHua,&Liu JinGang.(2011).Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats.WORLD JOURNAL OF GASTROENTEROLOGY,17(32),3739-3744.
MLA Bai Jie,et al."Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats".WORLD JOURNAL OF GASTROENTEROLOGY 17.32(2011):3739-3744.
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