Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index

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	Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index
其他题名	Cyclooxygenase 2 polymorphism and colorectal cancer: -765G＞C variant modifies risk associated with smoking and body mass index
	Xing LiLi; Wang ZhenNing; Jiang Li; Zhang Yong; Xu YingYing; Li Juan; Luo Yang; Zhang Xue
	2008
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
卷号	14 期号:11 页码:1785-1789
摘要	AIM: To explore whether cyclooxygenase 2 (COX-2) -765G > C polymorphism is associated with susceptibility of colorectal cancer (CRC) and to evaluate the risk of colorectal cancer in relation to environmental exposures and polymorphism.
其他摘要	AIM: To explore whether cyclooxygenase 2 (COX-2) -765G＞C polymorphism is associated with susceptibility of colorectal cancer (CRC) and to evaluate the risk of colorectal cancer in relation to environmental exposures and polymorphism.METHODS: We conducted a case-control study of 137 patients with colorectal cancer and 199 cancer-free controls in northeast China. Multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (OR) and 95% confidence interval (95% CI).RESULTS: The -765G＞C polymorphism was not independently associated with CRC risk. However, risk associated with the polymorphism differed by smoking and body mass index (BMI). Smoking and BMI associated risks were stronger among those with -765GG genotype, showing that smokers had a 2.682-fold greater risk of CRC than nonsmokers (51/43 vs 68/126, P = 0.006). Compared to those with a normal body mass index (BMI 18.5-22.9), those with overweight (BMI 23-24.9) had a 3.909-fold higher risk of CRC (OR = 3.909, 95% CI = 2.081-7.344; P ＜ 0.001), while those with obesity (BMI ＞ 25) had a 2.031- fold higher risk of CRC (OR = 1.107, 95% CI = 1.107-3.726; P = 0.022).CONCLUSION: Although COX-2 -765G＞C polymorphism is not associated with an increased risk of CRC, -765GG genotype appears to be related to an increased risk in the presence of smoking and higher BMI.
关键词	INFLAMMATORY-BOWEL-DISEASE SINGAPORE CHINESE HEALTH GENE INHIBITION GROWTH CELLS WOMEN colorectal cancer cyclooxygenase 2 polymorphism smoking body mass index
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3317335
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151778
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Xing LiLi,Wang ZhenNing,Jiang Li,et al. Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(11):1785-1789.
APA	Xing LiLi.,Wang ZhenNing.,Jiang Li.,Zhang Yong.,Xu YingYing.,...&Zhang Xue.(2008).Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index.WORLD JOURNAL OF GASTROENTEROLOGY,14(11),1785-1789.
MLA	Xing LiLi,et al."Cyclooxygenase 2 polymorphism and colorectal cancer: -765G > C variant modifies risk associated with smoking and body mass index".WORLD JOURNAL OF GASTROENTEROLOGY 14.11(2008):1785-1789.