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Characteristics of Arsenic Metabolites in Human Liver Hepatocytes
Alternative TitleCharacteristics of Arsenic Metabolites in Human Liver Hepatocytes
Cao Xuan1; Yu JingJing1; Gao Yang1; Sun JiChang1; Liu Yan1; Xu YuanYuan2; Sun GuiFan2; Wang XiaoRu1
2011
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
Volume39Issue:1Pages:1-6
AbstractHyphenated technique of high performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS) was applied to the determination of arsenic metabolites in Chang liver cells after arsenic incubation. Two unknown arsenicals were found, one of which was speculated as methylarsonous acid (MMA III), and further characterized using standard addition method using synthesized MMA III standard. Quantitative analysis results showed that mono-methylarsenicals, dimethylarsenicals and inorganic arsenicals in hepatocytes after arsenic incubation were increasing with the increase of initial incubated arsenic concentration while the methylation rate decreasing with the increase of initial incubated arsenic concentration, which indicated that high concentration of arsenic has the inhibition to the ability of arsenic methylation of Chang liver cells.
KeywordMONOMETHYLARSONOUS ACID URINE High performance liquid chromatography-inductively coupled plasma-mass spectrometry High performance liquid chromatography-time of flight-mass spectrometry Chang liver cells Arsenic metabolites Methylarsonous acid
Indexed ByCSCD
Language英语
CSCD IDCSCD:4114628
Citation statistics
Cited Times:3[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151785
Collection中国科学院金属研究所
Affiliation1.黑龙江省环境保护科学研究院
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Cao Xuan,Yu JingJing,Gao Yang,et al. Characteristics of Arsenic Metabolites in Human Liver Hepatocytes[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2011,39(1):1-6.
APA Cao Xuan.,Yu JingJing.,Gao Yang.,Sun JiChang.,Liu Yan.,...&Wang XiaoRu.(2011).Characteristics of Arsenic Metabolites in Human Liver Hepatocytes.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,39(1),1-6.
MLA Cao Xuan,et al."Characteristics of Arsenic Metabolites in Human Liver Hepatocytes".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 39.1(2011):1-6.
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