| Characteristics of Arsenic Metabolites in Human Liver Hepatocytes | |
| 其他题名 | Characteristics of Arsenic Metabolites in Human Liver Hepatocytes |
| Cao Xuan1; Yu JingJing1; Gao Yang1; Sun JiChang1; Liu Yan1; Xu YuanYuan2; Sun GuiFan2; Wang XiaoRu1 | |
| 2011 | |
| 发表期刊 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| ISSN | 0253-3820 |
| 卷号 | 39期号:1页码:1-6 |
| 摘要 | Hyphenated technique of high performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS) was applied to the determination of arsenic metabolites in Chang liver cells after arsenic incubation. Two unknown arsenicals were found, one of which was speculated as methylarsonous acid (MMA III), and further characterized using standard addition method using synthesized MMA III standard. Quantitative analysis results showed that mono-methylarsenicals, dimethylarsenicals and inorganic arsenicals in hepatocytes after arsenic incubation were increasing with the increase of initial incubated arsenic concentration while the methylation rate decreasing with the increase of initial incubated arsenic concentration, which indicated that high concentration of arsenic has the inhibition to the ability of arsenic methylation of Chang liver cells. |
| 关键词 | MONOMETHYLARSONOUS ACID URINE High performance liquid chromatography-inductively coupled plasma-mass spectrometry High performance liquid chromatography-time of flight-mass spectrometry Chang liver cells Arsenic metabolites Methylarsonous acid |
| 收录类别 | CSCD |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4114628 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/151785 |
| 专题 | 中国科学院金属研究所 |
| 作者单位 | 1.黑龙江省环境保护科学研究院 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Cao Xuan,Yu JingJing,Gao Yang,et al. Characteristics of Arsenic Metabolites in Human Liver Hepatocytes[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2011,39(1):1-6. |
| APA | Cao Xuan.,Yu JingJing.,Gao Yang.,Sun JiChang.,Liu Yan.,...&Wang XiaoRu.(2011).Characteristics of Arsenic Metabolites in Human Liver Hepatocytes.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,39(1),1-6. |
| MLA | Cao Xuan,et al."Characteristics of Arsenic Metabolites in Human Liver Hepatocytes".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 39.1(2011):1-6. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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