Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy

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	Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy
其他题名	Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy
	Yang Xiaofeng; Xu Yifeng; Lue Naiwu; Zhang Yibin; Wang Hongmei; Lue Xin; Cui Jiping; Zhou Jinxu; Shan Hong; Wu Yanxiang; Liu Xinping
	2011
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	6 期号:10 页码:785-789
摘要	Due to their relative abundance, stable biological properties and excellent reproductive activity, umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy, which is a muscular atrophy disease. Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion, in combination with multi-point intramuscular injection. They were followed up for 12 months after cell transplantation. Results showed that clinical symptoms significantly improved, daily living activity and muscle strength were enhanced, the sero-enzyme, electromyogram, and MRI scans showed improvement, and dystrophin was expressed in the muscle cell membrane. Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged, fibrous degeneration was alleviated, and fat infiltration was improved. These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.
其他摘要	Due to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy disease.Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular injection.They were followed up for 12 months after cell transplantation.Results showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell membrane.Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was improved.These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.
关键词	IN-VITRO ENDOTHELIAL-CELLS PROGENITOR CELLS CULTURE VIVO umbilical cord mesenchymal stem cells Duchenne muscular dystrophy case report dystrophin muscular force activities of daily living
收录类别	CSCD
语种	英语
资助项目	[Key Projects of Liaoning Province]
CSCD记录号	CSCD:4258073
引用统计	被引频次：4[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151818
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Yang Xiaofeng,Xu Yifeng,Lue Naiwu,et al. Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy[J]. NEURAL REGENERATION RESEARCH,2011,6(10):785-789.
APA	Yang Xiaofeng.,Xu Yifeng.,Lue Naiwu.,Zhang Yibin.,Wang Hongmei.,...&Liu Xinping.(2011).Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy.NEURAL REGENERATION RESEARCH,6(10),785-789.
MLA	Yang Xiaofeng,et al."Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy".NEURAL REGENERATION RESEARCH 6.10(2011):785-789.