IMR OpenIR
Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?
Alternative TitleRepair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors
Wang Yansong; Lue Gang
2010
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume5Issue:17Pages:1303-1307
AbstractBrain-derived neurotrophic factor (BDNF) can significantly promote nerve regeneration and repair. High expression of the BDNF-green fluorescent protein (GFP) gene persists for a long time after transfection into neural stem cells. Nevertheless, little is known about the biological characteristics of BDNF-GFP modified nerve stem cells in vivo and their ability to induce BDNF expression or repair spinal cord injury. In the present study, we transplanted BDNF-GFP transgenic neural stem cells into a hemisection model of rats. Rats with BDNF-GFP stem cells exhibited significantly increased BDNF expression and better locomotor function compared with stem cells alone. Cellular therapy with BDNF-GFP transgenic stem cells can improve outcomes better than stem cells alone and may have therapeutic potential for spinal cord injury.
Other AbstractBrain-derived neurotrophic factor (BDNF) can significantly promote nerve regeneration and repair. High expression of the BDNF-green fluorescent protein (GFP) gene persists for a long time after transfection into neural stem cells. Nevertheless, little is known about.the biological characteristics of BDNF-GFP modified nerve stem cells in vivo and their ability to induce BDNF expression or repair spinal cord injury. In the present study, we transplanted BDNF-GFP transgenic neural stem cells into a hemisection model of rats. Rats with BDNF-GFP stem cells exhibited significantly increased BDNF expression and better locomotor function compared with stem cells alone. Cellular therapy with BDNF-GFP transgenic stem cells can improve outcomes better than stem cells alone and may have therapeutic potential for spinal cord injury
KeywordFUNCTIONAL RECOVERY CORTICOSPINAL NEURONS PROGENITOR CELLS ADULT RATS LONG-TERM TRANSPLANTATION EXPRESSION BDNF NGF DIFFERENTIATION neural stem cells brain-derived neurotrophic factor transplantation green fluorescent protein spinal cord injury neural regeneration
Indexed ByCSCD
Language英语
Funding Project[Natural Science Foundation of Liaoning Province]
CSCD IDCSCD:4041465
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/151988
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Wang Yansong,Lue Gang. Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?[J]. NEURAL REGENERATION RESEARCH,2010,5(17):1303-1307.
APA Wang Yansong,&Lue Gang.(2010).Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?.NEURAL REGENERATION RESEARCH,5(17),1303-1307.
MLA Wang Yansong,et al."Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?".NEURAL REGENERATION RESEARCH 5.17(2010):1303-1307.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang Yansong]'s Articles
[Lue Gang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang Yansong]'s Articles
[Lue Gang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang Yansong]'s Articles
[Lue Gang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.