Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?

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	Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?
其他题名	Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors
	Wang Yansong; Lue Gang
	2010
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	5 期号:17 页码:1303-1307
摘要	Brain-derived neurotrophic factor (BDNF) can significantly promote nerve regeneration and repair. High expression of the BDNF-green fluorescent protein (GFP) gene persists for a long time after transfection into neural stem cells. Nevertheless, little is known about the biological characteristics of BDNF-GFP modified nerve stem cells in vivo and their ability to induce BDNF expression or repair spinal cord injury. In the present study, we transplanted BDNF-GFP transgenic neural stem cells into a hemisection model of rats. Rats with BDNF-GFP stem cells exhibited significantly increased BDNF expression and better locomotor function compared with stem cells alone. Cellular therapy with BDNF-GFP transgenic stem cells can improve outcomes better than stem cells alone and may have therapeutic potential for spinal cord injury.
其他摘要	Brain-derived neurotrophic factor (BDNF) can significantly promote nerve regeneration and repair. High expression of the BDNF-green fluorescent protein (GFP) gene persists for a long time after transfection into neural stem cells. Nevertheless, little is known about.the biological characteristics of BDNF-GFP modified nerve stem cells in vivo and their ability to induce BDNF expression or repair spinal cord injury. In the present study, we transplanted BDNF-GFP transgenic neural stem cells into a hemisection model of rats. Rats with BDNF-GFP stem cells exhibited significantly increased BDNF expression and better locomotor function compared with stem cells alone. Cellular therapy with BDNF-GFP transgenic stem cells can improve outcomes better than stem cells alone and may have therapeutic potential for spinal cord injury
关键词	FUNCTIONAL RECOVERY CORTICOSPINAL NEURONS PROGENITOR CELLS ADULT RATS LONG-TERM TRANSPLANTATION EXPRESSION BDNF NGF DIFFERENTIATION neural stem cells brain-derived neurotrophic factor transplantation green fluorescent protein spinal cord injury neural regeneration
收录类别	CSCD
语种	英语
资助项目	[Natural Science Foundation of Liaoning Province]
CSCD记录号	CSCD:4041465
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/151988
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Wang Yansong,Lue Gang. Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?[J]. NEURAL REGENERATION RESEARCH,2010,5(17):1303-1307.
APA	Wang Yansong,&Lue Gang.(2010).Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?.NEURAL REGENERATION RESEARCH,5(17),1303-1307.
MLA	Wang Yansong,et al."Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?".NEURAL REGENERATION RESEARCH 5.17(2010):1303-1307.