Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury

IMR OpenIR

	Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury
其他题名	Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury
	Li Fuyong 1; Han Shuai 1; Ma Yi 2; Yi Fuxin 3; Xu Xinmin 2; Liu Yunhui 1
	2014
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	9 期号:2 页码:179-189
摘要	Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, compression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 +/- 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demyelination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experimental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percutaneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.
其他摘要	Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, compression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 ± 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demyelination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experimental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percutaneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.
关键词	GANGLION BALLOON COMPRESSION GASSERIAN GANGLION LONG-TERM NEUROPATHIC PAIN MICROVASCULAR DECOMPRESSION TIC-DOULOUREUX NEURALGIA MICROCOMPRESSION EXPERIENCE MANAGEMENT nerve regeneration peripheral nerve injury trigeminal neuralgia percutaneous microballoon compression trigeminal ganglion cell demyelination axons vascular endothelial growth factor neural regeneration
收录类别	CSCD
语种	英语
资助项目	[Shengjing Hospital, China Medical University, China]
CSCD记录号	CSCD:5057691
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/152182
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Peoples Hosp Liaoning Prov, Department Neurosurg 2, Shenyang, Liaoning Provin, Peoples R China 3.First Affiliated Hosp, Liaoning Med Coll, Department Neurosurg 1, Jinzhou, Liaoning Provin, Peoples R China
推荐引用方式 GB/T 7714	Li Fuyong,Han Shuai,Ma Yi,et al. Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury[J]. NEURAL REGENERATION RESEARCH,2014,9(2):179-189.
APA	Li Fuyong,Han Shuai,Ma Yi,Yi Fuxin,Xu Xinmin,&Liu Yunhui.(2014).Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury.NEURAL REGENERATION RESEARCH,9(2),179-189.
MLA	Li Fuyong,et al."Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury".NEURAL REGENERATION RESEARCH 9.2(2014):179-189.