Hierarchical charge distribution controls self-assembly process of silk in vitro

IMR OpenIR

	Hierarchical charge distribution controls self-assembly process of silk in vitro
其他题名	Hierarchical charge distribution controls self-assembly process of silk in vitro
	Zhang Yi 1; Zhang Cencen 1; Liu Lijie 1; Kaplan David L 1; Zhu Hesun 4; Lu Qiang 1
	2015
发表期刊	FRONTIERS OF MATERIALS SCIENCE
ISSN	2095-025X
卷号	9 期号:4 页码:382-391
摘要	Silk materials with different nanostructures have been developed without the understanding of the inherent transformation mechanism. Here we attempt to reveal the conversion road of the various nanostructures and determine the critical regulating factors. The regulating conversion processes influenced by a hierarchical charge distribution were investigated, showing different transformations between molecules, nanoparticles and nanofibers. Various repulsion and compressive forces existed among silk fibroin molecules and aggregates due to the exterior and interior distribution of charge, which further controlled their aggregating and deaggregating behaviors and finally formed nanofibers with different sizes. Synergistic action derived from molecular mobility and concentrations could also tune the assembly process and final nanostructures. It is suggested that the complicated silk fibroin assembly processes comply a same rule based on charge distribution, offering a promising way to develop silk-based materials with designed nanostructures.
其他摘要	Silk materials with different nanostructures have been developed without the understanding of the inherent transformation mechanism. Here we attempt to reveal the conversion road of the various nanostructures and determine the critical regulating factors. The regulating conversion processes influenced by a hierarchical charqe distribution were investigated, showing different transformations between molecules, nanoparticles and nanofibers. Various repulsion and compressive forces existed among silk fibroin molecules and aggregates due to the exterior and interior distribution of charge,which further controlled their aggregating and deaggregating behaviors and finally formed nanofibers with different sizes. Synergistic action derived from molecular mobility and concentrations could also tune the assembly process and final nanostructures. It is suggested that the complicated silk fibroin assembly processes comply a same rule based on charge distribution, offering a promising way to develop silk-based materials with designed nanostructures.
关键词	ATOMIC-FORCE MICROSCOPY SPIDER DRAGLINE SILK FIBROIN NANOFIBERS PROTEIN PH NANOSTRUCTURE MECHANISMS TOUGHNESS STRENGTH SCAFFOLDS silk self-assembly charge nanostructure nanofiber
收录类别	CSCD
语种	英语
资助项目	[National Basic Research Program of China (973 Program)] ; [National Natural Science Foundation of China] ; [Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)] ; [Excellent Youth Foundation of Jiangsu Province] ; [International S&T Cooperation Project of the Ministry of ST of China] ; [Key Natural Science Foundation of the Jiangsu Higher Education Institutions of China] ; [Jiangsu Provincial Special Program of Medical Science]
CSCD记录号	CSCD:5594201
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/152316
专题	中国科学院金属研究所
作者单位	1.苏州大学 2.Henan Institute Engn, Coll Text, Zhengzhou 450007, Peoples R China 3.塔夫茨大学 4.中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhang Yi,Zhang Cencen,Liu Lijie,et al. Hierarchical charge distribution controls self-assembly process of silk in vitro[J]. FRONTIERS OF MATERIALS SCIENCE,2015,9(4):382-391.
APA	Zhang Yi,Zhang Cencen,Liu Lijie,Kaplan David L,Zhu Hesun,&Lu Qiang.(2015).Hierarchical charge distribution controls self-assembly process of silk in vitro.FRONTIERS OF MATERIALS SCIENCE,9(4),382-391.
MLA	Zhang Yi,et al."Hierarchical charge distribution controls self-assembly process of silk in vitro".FRONTIERS OF MATERIALS SCIENCE 9.4(2015):382-391.