| Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry | |
| Alternative Title | Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry |
| Xu Ke1; Wang Fei2 | |
| 2013 | |
| Source Publication | NEUROSCIENCE BULLETIN
 |
| ISSN | 1673-7067 |
| Volume | 29Issue:1Pages:1-2 |
| Abstract | Anxiety and depression are highly heritable disorders that lead to significant impairment in affected individuals across gender,ethnicity and race;these disorders are frequently the leading causes of disability and suicide in many countries.One could assume that the same pathophysiological mechanisms underlie anxiety and depression in all affected individuals; however, the observed clinical heterogeneity within these disorders raises doubts and questions as to the validity of this assumption. Moreover, no single gene is thought to underlie anxiety and depression. Instead, it is thought that a convergence of multiple genetic factors contributes to the clinical manifestations of these disorders, adding yet another layer of complexity to understanding the pathophysiology of anxiety and depression. |
| Other Abstract | Anxiety and depression are highly heritable disorders that lead to significant impairment in affected individuals across gender,ethnicity and race;these disorders are frequently the leading causes of disability and suicide in many countries.One could assume that the same pathophysiological mechanisms underlie anxiety and depression in all affected individuals; however, the observed clinical heterogeneity within these disorders raises doubts and questions as to the validity of this assumption. Moreover, no single gene is thought to underlie anxiety and depression. Instead, it is thought that a convergence of multiple genetic factors contributes to the clinical manifestations of these disorders, adding yet another layer of complexity to understanding the pathophysiology of anxiety and depression. |
| Keyword | SEROTONIN TRANSPORTER GENE MAJOR DEPRESSIVE DISORDER POLYMORPHISM ABNORMALITIES PERSPECTIVES |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:4784523 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/152445 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.耶鲁大学 |
| Recommended Citation GB/T 7714 | Xu Ke,Wang Fei. Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry[J]. NEUROSCIENCE BULLETIN,2013,29(1):1-2. |
| APA | Xu Ke,&Wang Fei.(2013).Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry.NEUROSCIENCE BULLETIN,29(1),1-2. |
| MLA | Xu Ke,et al."Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry".NEUROSCIENCE BULLETIN 29.1(2013):1-2. |
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