Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry

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	Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry
其他题名	Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry
	Xu Ke 1; Wang Fei 2
	2013
发表期刊	NEUROSCIENCE BULLETIN
ISSN	1673-7067
卷号	29 期号:1 页码:1-2
摘要	Anxiety and depression are highly heritable disorders that lead to significant impairment in affected individuals across gender,ethnicity and race;these disorders are frequently the leading causes of disability and suicide in many countries.One could assume that the same pathophysiological mechanisms underlie anxiety and depression in all affected individuals; however, the observed clinical heterogeneity within these disorders raises doubts and questions as to the validity of this assumption. Moreover, no single gene is thought to underlie anxiety and depression. Instead, it is thought that a convergence of multiple genetic factors contributes to the clinical manifestations of these disorders, adding yet another layer of complexity to understanding the pathophysiology of anxiety and depression.
其他摘要	Anxiety and depression are highly heritable disorders that lead to significant impairment in affected individuals across gender,ethnicity and race;these disorders are frequently the leading causes of disability and suicide in many countries.One could assume that the same pathophysiological mechanisms underlie anxiety and depression in all affected individuals; however, the observed clinical heterogeneity within these disorders raises doubts and questions as to the validity of this assumption. Moreover, no single gene is thought to underlie anxiety and depression. Instead, it is thought that a convergence of multiple genetic factors contributes to the clinical manifestations of these disorders, adding yet another layer of complexity to understanding the pathophysiology of anxiety and depression.
关键词	SEROTONIN TRANSPORTER GENE MAJOR DEPRESSIVE DISORDER POLYMORPHISM ABNORMALITIES PERSPECTIVES
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4784523
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/152445
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.耶鲁大学
推荐引用方式 GB/T 7714	Xu Ke,Wang Fei. Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry[J]. NEUROSCIENCE BULLETIN,2013,29(1):1-2.
APA	Xu Ke,&Wang Fei.(2013).Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry.NEUROSCIENCE BULLETIN,29(1),1-2.
MLA	Xu Ke,et al."Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry".NEUROSCIENCE BULLETIN 29.1(2013):1-2.