| Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives | |
| Yu Fuqiang1; Guan Aiying2; Li Mengru2; Hu Lan2; Li Xiaowu1 | |
| 2018 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 29Issue:6Pages:915-918 |
| Abstract | Employing the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified by H-1 NMR,C-13 NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB) and sorghum anthracnose (SA) were evaluated by the mycelium linear growth rate method. Compounds 4,16 and 20 displayed significant activities against RSB (EC50 = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC50 = 1.03 mg/L), equal to commercial pyraclostrobin (EC50= 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| Other Abstract | Employing the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moietywere designed and synthesized. The structures of the title compounds were identified by ~1H NMR, ~(13)C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB)and sorghum anthracnose (SA)were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB (EC_(50) = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC_(50) = 1.03 mg/L), equal to commercial pyraclostrobin (EC_(50) = 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development. |
| Keyword | INSECTICIDAL ACTIVITIES SAR 1,3,4-Oxadiazole derivatives Intermediate derivatization method Rice sheath blight Sorghum anthracnose Structure-activity relationship |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Open Foundation of Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, China] |
| CSCD ID | CSCD:6275686 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/152497 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.上海市地震局 2.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Yu Fuqiang,Guan Aiying,Li Mengru,et al. Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives[J]. CHINESE CHEMICAL LETTERS,2018,29(6):915-918. |
| APA | Yu Fuqiang,Guan Aiying,Li Mengru,Hu Lan,&Li Xiaowu.(2018).Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives.CHINESE CHEMICAL LETTERS,29(6),915-918. |
| MLA | Yu Fuqiang,et al."Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives".CHINESE CHEMICAL LETTERS 29.6(2018):915-918. |
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