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Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives
Yu Fuqiang1; Guan Aiying2; Li Mengru2; Hu Lan2; Li Xiaowu1
2018
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume29Issue:6Pages:915-918
AbstractEmploying the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified by H-1 NMR,C-13 NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB) and sorghum anthracnose (SA) were evaluated by the mycelium linear growth rate method. Compounds 4,16 and 20 displayed significant activities against RSB (EC50 = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC50 = 1.03 mg/L), equal to commercial pyraclostrobin (EC50= 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Other AbstractEmploying the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moietywere designed and synthesized. The structures of the title compounds were identified by ~1H NMR, ~(13)C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB)and sorghum anthracnose (SA)were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB (EC_(50) = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC_(50) = 1.03 mg/L), equal to commercial pyraclostrobin (EC_(50) = 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development.
KeywordINSECTICIDAL ACTIVITIES SAR 1,3,4-Oxadiazole derivatives Intermediate derivatization method Rice sheath blight Sorghum anthracnose Structure-activity relationship
Indexed ByCSCD
Language英语
Funding Project[Open Foundation of Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, China]
CSCD IDCSCD:6275686
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/152497
Collection中国科学院金属研究所
Affiliation1.上海市地震局
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Yu Fuqiang,Guan Aiying,Li Mengru,et al. Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives[J]. CHINESE CHEMICAL LETTERS,2018,29(6):915-918.
APA Yu Fuqiang,Guan Aiying,Li Mengru,Hu Lan,&Li Xiaowu.(2018).Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives.CHINESE CHEMICAL LETTERS,29(6),915-918.
MLA Yu Fuqiang,et al."Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives".CHINESE CHEMICAL LETTERS 29.6(2018):915-918.
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