| Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier | |
| Alternative Title | Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier |
| Jiang Hanwei1; Wang Liu1; Cui Yingxia2; Xu Zhipeng2; Guo Tonghang3; Cheng Dongkai4; Xu Peng4; Yu Wen2; Shi Qinghua1 | |
| 2014 | |
| Source Publication | JOURNAL OF GENETICS AND GENOMICS
 |
| ISSN | 1673-8527 |
| Volume | 41Issue:3Pages:177-185 |
| Abstract | Reciprocal translocation is one of the most common structural chromosomal rearrangements in human beings; it is widely recognized to be associated with male infertility. This association is mainly based on the abnormal chromosome behavior of the translocated chromosomes and sex chromosomes during meiosis prophase I in reciprocal translocation carriers. However, the underlying mechanisms are not completely known. Here we report a reciprocal translocation carrier of t(8;15), who is oligozoospermic due to apoptosis of primary spermatocytes and to premature germ cell desquamation from seminiferous tubules. Further analysis showed abnormal synapsis and recombination frequency in this patient, indicating a connection between chromosome behavior and apoptosis of primary spermatocytes. We also compared these observations with recently reported findings on spermatogenesis defects in reciprocal translocation carriers, and discuss the possible mechanisms underlying both common and unique phenotypes of reciprocal translocations involving different chromosomes with the aim of further understanding the regulation of human spermatogenesis. |
| Other Abstract | Reciprocal translocation is one of the most common structural chromosomal rearrangements in human beings; it is widely recognized to be associated with male infertility. This association is mainly based on the abnormal chromosome behavior of the translocated chromosomes and sex chromosomes during meiosis prophase I in reciprocal translocation carriers. However, the underlying mechanisms are not completely known. Here we report a reciprocal translocation carrier of t(8;15), who is oligozoospermic due to apoptosis of primary spermatocytes and to premature germ cell desquamation from seminiferous tubules. Further analysis showed abnormal synapsis and recombination frequency in this patient, indicating a connection between chromosome behavior and apoptosis of primary spermatocytes. We also compared these observations with recently reported findings on spermatogenesis defects in reciprocal translocation carriers, and discuss the possible mechanisms underlying both common and unique phenotypes of reciprocal translocations involving different chromosomes with the aim of further understanding the regulation of human spermatogenesis. |
| Keyword | RECIPROCAL TRANSLOCATION CARRIERS MALE-INFERTILITY RECOMBINATION QUADRIVALENT MEN ASSOCIATION ASYNAPSIS ABNORMALITIES SEGREGATION SPERMATOZOA Chromosomal translocation Oligozoospermia Meiosis Synaptonemal complex Recombination Transcriptional inactivation |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Basic Research Program of China (973 Program) of China] ; [National Natural Science Foundation of China] ; [Chinese Academy of Sciences] |
| CSCD ID | CSCD:5097185 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/152793 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学技术大学 2.南京大学 3.Anhui Med University, Ctr Reprod Med, Affiliated Prov Hosp, Hefei 230061, Peoples R China 4.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Jiang Hanwei,Wang Liu,Cui Yingxia,et al. Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier[J]. JOURNAL OF GENETICS AND GENOMICS,2014,41(3):177-185. |
| APA | Jiang Hanwei.,Wang Liu.,Cui Yingxia.,Xu Zhipeng.,Guo Tonghang.,...&Shi Qinghua.(2014).Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier.JOURNAL OF GENETICS AND GENOMICS,41(3),177-185. |
| MLA | Jiang Hanwei,et al."Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier".JOURNAL OF GENETICS AND GENOMICS 41.3(2014):177-185. |
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