Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier

IMR OpenIR

	Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier
其他题名	Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier
	Jiang Hanwei 1; Wang Liu 1; Cui Yingxia 2; Xu Zhipeng 2; Guo Tonghang 3; Cheng Dongkai 4; Xu Peng 4; Yu Wen 2; Shi Qinghua 1
	2014
发表期刊	JOURNAL OF GENETICS AND GENOMICS
ISSN	1673-8527
卷号	41 期号:3 页码:177-185
摘要	Reciprocal translocation is one of the most common structural chromosomal rearrangements in human beings; it is widely recognized to be associated with male infertility. This association is mainly based on the abnormal chromosome behavior of the translocated chromosomes and sex chromosomes during meiosis prophase I in reciprocal translocation carriers. However, the underlying mechanisms are not completely known. Here we report a reciprocal translocation carrier of t(8;15), who is oligozoospermic due to apoptosis of primary spermatocytes and to premature germ cell desquamation from seminiferous tubules. Further analysis showed abnormal synapsis and recombination frequency in this patient, indicating a connection between chromosome behavior and apoptosis of primary spermatocytes. We also compared these observations with recently reported findings on spermatogenesis defects in reciprocal translocation carriers, and discuss the possible mechanisms underlying both common and unique phenotypes of reciprocal translocations involving different chromosomes with the aim of further understanding the regulation of human spermatogenesis.
其他摘要	Reciprocal translocation is one of the most common structural chromosomal rearrangements in human beings; it is widely recognized to be associated with male infertility. This association is mainly based on the abnormal chromosome behavior of the translocated chromosomes and sex chromosomes during meiosis prophase I in reciprocal translocation carriers. However, the underlying mechanisms are not completely known. Here we report a reciprocal translocation carrier of t(8;15), who is oligozoospermic due to apoptosis of primary spermatocytes and to premature germ cell desquamation from seminiferous tubules. Further analysis showed abnormal synapsis and recombination frequency in this patient, indicating a connection between chromosome behavior and apoptosis of primary spermatocytes. We also compared these observations with recently reported findings on spermatogenesis defects in reciprocal translocation carriers, and discuss the possible mechanisms underlying both common and unique phenotypes of reciprocal translocations involving different chromosomes with the aim of further understanding the regulation of human spermatogenesis.
关键词	RECIPROCAL TRANSLOCATION CARRIERS MALE-INFERTILITY RECOMBINATION QUADRIVALENT MEN ASSOCIATION ASYNAPSIS ABNORMALITIES SEGREGATION SPERMATOZOA Chromosomal translocation Oligozoospermia Meiosis Synaptonemal complex Recombination Transcriptional inactivation
收录类别	CSCD
语种	英语
资助项目	[National Basic Research Program of China (973 Program) of China] ; [National Natural Science Foundation of China] ; [Chinese Academy of Sciences]
CSCD记录号	CSCD:5097185
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/152795
专题	中国科学院金属研究所
作者单位	1.中国科学技术大学 2.南京大学 3.Anhui Med University, Ctr Reprod Med, Affiliated Prov Hosp, Hefei 230061, Peoples R China 4.中国科学院金属研究所
推荐引用方式 GB/T 7714	Jiang Hanwei,Wang Liu,Cui Yingxia,et al. Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier[J]. JOURNAL OF GENETICS AND GENOMICS,2014,41(3):177-185.
APA	Jiang Hanwei.,Wang Liu.,Cui Yingxia.,Xu Zhipeng.,Guo Tonghang.,...&Shi Qinghua.(2014).Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier.JOURNAL OF GENETICS AND GENOMICS,41(3),177-185.
MLA	Jiang Hanwei,et al."Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier".JOURNAL OF GENETICS AND GENOMICS 41.3(2014):177-185.