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Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier
Alternative TitleMeiotic Chromosome Behavior in a Human Male t(8;15) Carrier
Jiang Hanwei1; Wang Liu1; Cui Yingxia2; Xu Zhipeng2; Guo Tonghang3; Cheng Dongkai4; Xu Peng4; Yu Wen2; Shi Qinghua1
2014
Source PublicationJOURNAL OF GENETICS AND GENOMICS
ISSN1673-8527
Volume41Issue:3Pages:177-185
AbstractReciprocal translocation is one of the most common structural chromosomal rearrangements in human beings; it is widely recognized to be associated with male infertility. This association is mainly based on the abnormal chromosome behavior of the translocated chromosomes and sex chromosomes during meiosis prophase I in reciprocal translocation carriers. However, the underlying mechanisms are not completely known. Here we report a reciprocal translocation carrier of t(8;15), who is oligozoospermic due to apoptosis of primary spermatocytes and to premature germ cell desquamation from seminiferous tubules. Further analysis showed abnormal synapsis and recombination frequency in this patient, indicating a connection between chromosome behavior and apoptosis of primary spermatocytes. We also compared these observations with recently reported findings on spermatogenesis defects in reciprocal translocation carriers, and discuss the possible mechanisms underlying both common and unique phenotypes of reciprocal translocations involving different chromosomes with the aim of further understanding the regulation of human spermatogenesis.
Other AbstractReciprocal translocation is one of the most common structural chromosomal rearrangements in human beings; it is widely recognized to be associated with male infertility. This association is mainly based on the abnormal chromosome behavior of the translocated chromosomes and sex chromosomes during meiosis prophase I in reciprocal translocation carriers. However, the underlying mechanisms are not completely known. Here we report a reciprocal translocation carrier of t(8;15), who is oligozoospermic due to apoptosis of primary spermatocytes and to premature germ cell desquamation from seminiferous tubules. Further analysis showed abnormal synapsis and recombination frequency in this patient, indicating a connection between chromosome behavior and apoptosis of primary spermatocytes. We also compared these observations with recently reported findings on spermatogenesis defects in reciprocal translocation carriers, and discuss the possible mechanisms underlying both common and unique phenotypes of reciprocal translocations involving different chromosomes with the aim of further understanding the regulation of human spermatogenesis.
KeywordRECIPROCAL TRANSLOCATION CARRIERS MALE-INFERTILITY RECOMBINATION QUADRIVALENT MEN ASSOCIATION ASYNAPSIS ABNORMALITIES SEGREGATION SPERMATOZOA Chromosomal translocation Oligozoospermia Meiosis Synaptonemal complex Recombination Transcriptional inactivation
Indexed ByCSCD
Language英语
Funding Project[National Basic Research Program of China (973 Program) of China] ; [National Natural Science Foundation of China] ; [Chinese Academy of Sciences]
CSCD IDCSCD:5097185
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/152795
Collection中国科学院金属研究所
Affiliation1.中国科学技术大学
2.南京大学
3.Anhui Med University, Ctr Reprod Med, Affiliated Prov Hosp, Hefei 230061, Peoples R China
4.中国科学院金属研究所
Recommended Citation
GB/T 7714
Jiang Hanwei,Wang Liu,Cui Yingxia,et al. Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier[J]. JOURNAL OF GENETICS AND GENOMICS,2014,41(3):177-185.
APA Jiang Hanwei.,Wang Liu.,Cui Yingxia.,Xu Zhipeng.,Guo Tonghang.,...&Shi Qinghua.(2014).Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier.JOURNAL OF GENETICS AND GENOMICS,41(3),177-185.
MLA Jiang Hanwei,et al."Meiotic Chromosome Behavior in a Human Male t(8;15) Carrier".JOURNAL OF GENETICS AND GENOMICS 41.3(2014):177-185.
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