Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives

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	Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives
其他题名	Design, Synthesis and Antifungal Activity of 6-Fluoro-3, 3a, 4, 5-tetrahydro-2H-pyrazolo 4, 3-c-quinoline-2-carboxamide Derivatives
	Yuan Jing; Su Xin; Zhang Xin; Cong Lin; Guo Chun
	2011
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	27 期号:6 页码:955-957
摘要	A series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-cquinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry(MS) and H-1 NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities, against the tested fungi at different levels.
其他摘要	A series of 6-fluoro-3, 3a, 4, 5-tetrahydro-2H-pyrazolo4, 3-cquinoline-2-carboxanide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry(MS) and 'H NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.
关键词	BIOLOGICAL-ACTIVITIES AGENTS 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-cquinoline-2-carboxamide derivative Cysteine protease inhibitor Antifungal activity
收录类别	CSCD
语种	英语
资助项目	[National Science and Technology Major Projects of China]
CSCD记录号	CSCD:4377190
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/152927
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Yuan Jing,Su Xin,Zhang Xin,et al. Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2011,27(6):955-957.
APA	Yuan Jing,Su Xin,Zhang Xin,Cong Lin,&Guo Chun.(2011).Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,27(6),955-957.
MLA	Yuan Jing,et al."Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 27.6(2011):955-957.