| Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy | |
| Alternative Title | Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy |
| Shi Kai1; Haynes Matthew1; Huang Leaf1 | |
| 2017 | |
| Source Publication | FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
 |
| ISSN | 2095-0179 |
| Volume | 11Issue:4Pages:676-684 |
| Abstract | Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitopeassociated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems in vitro and in vivo, an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success. |
| Other Abstract | Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitope-associated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems in vitro and in vivo, an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success. |
| Keyword | ANTITUMOR IMMUNE-RESPONSES T-CELL RESPONSES CALCIUM-PHOSPHATE NANOPARTICLES IN-VIVO INDOLEAMINE 2,3-DIOXYGENASE DENDRITIC CELLS REGULATORY T ANTIGEN PRESENTATION DNA VACCINE IMMUNOSUPPRESSIVE NETWORKS vaccine nanoparticle tumor immunotherapy microenvironment |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [NIH] ; [National Natural Science Foundation of China] |
| CSCD ID | CSCD:6114002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/153299 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.University North Carolina Chapel Hill, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA 2.University North Carolina Chapel Hill, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA 3.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Shi Kai,Haynes Matthew,Huang Leaf. Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy[J]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2017,11(4):676-684. |
| APA | Shi Kai,Haynes Matthew,&Huang Leaf.(2017).Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy.FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,11(4),676-684. |
| MLA | Shi Kai,et al."Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy".FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 11.4(2017):676-684. |
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