Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

IMR OpenIR

	Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy
其他题名	Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy
	Shi Kai 1; Haynes Matthew 1; Huang Leaf 1
	2017
发表期刊	FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
ISSN	2095-0179
卷号	11 期号:4 页码:676-684
摘要	Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitopeassociated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems in vitro and in vivo, an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.
其他摘要	Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitope-associated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems in vitro and in vivo, an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.
关键词	ANTITUMOR IMMUNE-RESPONSES T-CELL RESPONSES CALCIUM-PHOSPHATE NANOPARTICLES IN-VIVO INDOLEAMINE 2,3-DIOXYGENASE DENDRITIC CELLS REGULATORY T ANTIGEN PRESENTATION DNA VACCINE IMMUNOSUPPRESSIVE NETWORKS vaccine nanoparticle tumor immunotherapy microenvironment
收录类别	CSCD
语种	英语
资助项目	[NIH] ; [National Natural Science Foundation of China]
CSCD记录号	CSCD:6114002
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/153299
专题	中国科学院金属研究所
作者单位	1.University North Carolina Chapel Hill, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA 2.University North Carolina Chapel Hill, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA 3.中国科学院金属研究所
推荐引用方式 GB/T 7714	Shi Kai,Haynes Matthew,Huang Leaf. Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy[J]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2017,11(4):676-684.
APA	Shi Kai,Haynes Matthew,&Huang Leaf.(2017).Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy.FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,11(4),676-684.
MLA	Shi Kai,et al."Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy".FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 11.4(2017):676-684.