| Study of spatial signal transduction in bistable switches | |
| Alternative Title | Study of spatial signal transduction in bistable switches |
| Zhao Qi1; Yao ChengGui3; Tang Jun4; Liu LiWei5 | |
| 2016 | |
| Source Publication | FRONTIERS OF PHYSICS
 |
| ISSN | 2095-0462 |
| Volume | 11Issue:5 |
| Abstract | Bistable switch modules are among the most important fundamental motifs in signal-transduction pathways. To better understand their spatial signal transduction, we model the diffusion process in the one-dimensional (1-D) domain. We find that when none of the elements diffuse, the response of the system exhibits a spatial switch-like property. However, when one of the elements is highly diffusible, the response of the system does not show any spatial switching behavior. Furthermore, we observe that the spatial responses of the system are more sensitive to the time constant of the switch when none of the elements are diffusible. Further, a slow loop keeps the system in the high steady state more positions than that in the fast loop. Finally, we consolidate our numerical results analytically by performing a mathematical method. |
| Other Abstract | Bistable switch modules are among the most important fundamental motifs in signal-transduction pathways. To better understand their spatial signal transduction, we model the diffusion process in the one-dimensional (1-D) domain. We find that when none of the elements diffuse, the response of the system exhibits a spatial switch-like property. However, when one of the elements is highly diffusible, the response of the system does not show any spatial switching behavior. Furthermore, we observe that the spatial responses of the system are more sensitive to the time constant of the switch when none of the elements are diffusible. Further, a slow loop keeps the system in the high steady state more positions than that in the fast loop. Finally, we consolidate our numerical results analytically by performing a mathematical method. |
| Keyword | PROTEIN-KINASE CASCADES POSITIVE-FEEDBACK NEGATIVE FEEDBACK CELL POLARITY BISTABILITY GRADIENTS ULTRASENSITIVITY OSCILLATIONS ACTIVATION OOCYTES signal processing reaction-diffusion model nonlinear dynamics spatial switch |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Education Department of Liaoning Province] |
| CSCD ID | CSCD:5881345 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/153747 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.辽宁大学 2.中国科学院金属研究所 3.绍兴文理学院 4.China University Min & Technol, Coll Sci, Xuzhou 221008, Peoples R China 5.大连交通大学 |
| Recommended Citation GB/T 7714 | Zhao Qi,Yao ChengGui,Tang Jun,et al. Study of spatial signal transduction in bistable switches[J]. FRONTIERS OF PHYSICS,2016,11(5). |
| APA | Zhao Qi,Yao ChengGui,Tang Jun,&Liu LiWei.(2016).Study of spatial signal transduction in bistable switches.FRONTIERS OF PHYSICS,11(5). |
| MLA | Zhao Qi,et al."Study of spatial signal transduction in bistable switches".FRONTIERS OF PHYSICS 11.5(2016). |
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