Study of spatial signal transduction in bistable switches

IMR OpenIR

	Study of spatial signal transduction in bistable switches
其他题名	Study of spatial signal transduction in bistable switches
	Zhao Qi 1; Yao ChengGui 3; Tang Jun 4; Liu LiWei 5
	2016
发表期刊	FRONTIERS OF PHYSICS
ISSN	2095-0462
卷号	11 期号:5
摘要	Bistable switch modules are among the most important fundamental motifs in signal-transduction pathways. To better understand their spatial signal transduction, we model the diffusion process in the one-dimensional (1-D) domain. We find that when none of the elements diffuse, the response of the system exhibits a spatial switch-like property. However, when one of the elements is highly diffusible, the response of the system does not show any spatial switching behavior. Furthermore, we observe that the spatial responses of the system are more sensitive to the time constant of the switch when none of the elements are diffusible. Further, a slow loop keeps the system in the high steady state more positions than that in the fast loop. Finally, we consolidate our numerical results analytically by performing a mathematical method.
其他摘要	Bistable switch modules are among the most important fundamental motifs in signal-transduction pathways. To better understand their spatial signal transduction, we model the diffusion process in the one-dimensional (1-D) domain. We find that when none of the elements diffuse, the response of the system exhibits a spatial switch-like property. However, when one of the elements is highly diffusible, the response of the system does not show any spatial switching behavior. Furthermore, we observe that the spatial responses of the system are more sensitive to the time constant of the switch when none of the elements are diffusible. Further, a slow loop keeps the system in the high steady state more positions than that in the fast loop. Finally, we consolidate our numerical results analytically by performing a mathematical method.
关键词	PROTEIN-KINASE CASCADES POSITIVE-FEEDBACK NEGATIVE FEEDBACK CELL POLARITY BISTABILITY GRADIENTS ULTRASENSITIVITY OSCILLATIONS ACTIVATION OOCYTES signal processing reaction-diffusion model nonlinear dynamics spatial switch
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Education Department of Liaoning Province]
CSCD记录号	CSCD:5881345
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/153747
专题	中国科学院金属研究所
作者单位	1.辽宁大学 2.中国科学院金属研究所 3.绍兴文理学院 4.China University Min & Technol, Coll Sci, Xuzhou 221008, Peoples R China 5.大连交通大学
推荐引用方式 GB/T 7714	Zhao Qi,Yao ChengGui,Tang Jun,et al. Study of spatial signal transduction in bistable switches[J]. FRONTIERS OF PHYSICS,2016,11(5).
APA	Zhao Qi,Yao ChengGui,Tang Jun,&Liu LiWei.(2016).Study of spatial signal transduction in bistable switches.FRONTIERS OF PHYSICS,11(5).
MLA	Zhao Qi,et al."Study of spatial signal transduction in bistable switches".FRONTIERS OF PHYSICS 11.5(2016).