| Catalytic synthesis methods for triazolopyrimidine derivatives | |
| Alternative Title | Catalytic Synthesis Methods for Triazolopyrimidine Derivatives |
| Cheng ChunSheng; Gai YongMing; Wang XinLei; Peng Jun | |
| 2008 | |
| Source Publication | CHINESE JOURNAL OF CHEMISTRY
 |
| ISSN | 1001-604X |
| Volume | 26Issue:7Pages:1291-1294 |
| Abstract | A new method for catalyzed synthesis of triazolopyrimidine derivatives is reported. Alkylamine reaction with dialkyl cyanodithioiminocarbonate was catalyzed by quaternary ammonium salts at room temperature to yield 3-alkylamine-5-amino-1,2,4-triazole in good quality and high yields. After imidization and reaction with an alpha,beta-unsaturated acid derivative, the reaction intermediate was hydrolyzed in the presence of a Lewis acid to obtain the target product. This novel catalytic method for triazolopyrimidine derivatives can be carried out under inexpensive and mild conditions, and is safe and environmentally friendly. (1)H NMR results for all intermediates are reported. |
| Other Abstract | A new method for catalyzed synthesis of triazolopyrimidine derivatives is reported. Alkylamine reaction with dialkyl cyanodithioiminocarbonate was catalyzed by quaternary ammonium salts at room temperature to yield 3-alkylamine-5-amino-1,2,4-triazole in good quality and high yields. After imidization and reaction with an ,-unsaturated acid derivative, the reaction intermediate was hydrolyzed in the presence of a Lewis acid to obtain the target product. This novel catalytic method for triazolopyrimidine derivatives can be carried out under inexpensive and mild conditions, and is safe and environmentally friendly. 1H NMR results for all intermediates are reported. |
| Keyword | PARAQUAT triazolopyrimidine derivative catalyst Lewis acid green chemistry |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3434908 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/153776 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Cheng ChunSheng,Gai YongMing,Wang XinLei,et al. Catalytic synthesis methods for triazolopyrimidine derivatives[J]. CHINESE JOURNAL OF CHEMISTRY,2008,26(7):1291-1294. |
| APA | Cheng ChunSheng,Gai YongMing,Wang XinLei,&Peng Jun.(2008).Catalytic synthesis methods for triazolopyrimidine derivatives.CHINESE JOURNAL OF CHEMISTRY,26(7),1291-1294. |
| MLA | Cheng ChunSheng,et al."Catalytic synthesis methods for triazolopyrimidine derivatives".CHINESE JOURNAL OF CHEMISTRY 26.7(2008):1291-1294. |
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