| Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases | |
| Alternative Title | Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases |
| Gao Xinghua; Chen Hongduo | |
| 2014 | |
| Source Publication | FRONTIERS OF MEDICINE
 |
| ISSN | 2095-0217 |
| Volume | 8Issue:1Pages:1-5 |
| Abstract | Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39 degrees C to 40 degrees C) can modulate the activities of immune cells, including antigen-presenting cells, T cells, and natural killer cells. Heat shock temperature (41 degrees C to 43 degrees C) can increase the immunogenicity of tumor cells. Cytotoxic temperature (> 43 degrees C) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia. |
| Other Abstract | Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39 ℃ to 40 ℃) can modulate the activities of immune cells, including antigen-presenting cells, Tcells, and natural killer cells. Heat shock temperature (41 ℃ to 43 ℃) can increase the immunogenicity of tumor cells. Cytotoxic temperature (> 43 ℃) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia. |
| Keyword | hyperthermia HPV immune response virus tumor |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Innovative Research Teams of Liaoning Department of Education] ; [Public Welfare Research Fund for Healthcare] |
| CSCD ID | CSCD:5100113 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/153813 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Gao Xinghua,Chen Hongduo. Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases[J]. FRONTIERS OF MEDICINE,2014,8(1):1-5. |
| APA | Gao Xinghua,&Chen Hongduo.(2014).Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases.FRONTIERS OF MEDICINE,8(1),1-5. |
| MLA | Gao Xinghua,et al."Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected skin diseases".FRONTIERS OF MEDICINE 8.1(2014):1-5. |
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