| Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori? | |
| Alternative Title | Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori ? |
| Song HanYi; Li Yan | |
| 2013 | |
| Source Publication | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| ISSN | 1007-9327 |
| Volume | 19Issue:39Pages:6645-6650 |
| Abstract | AIM: To evaluate the influence of oral Helicobacter pylori (H. pylori) on the success of eradication therapy against gastric H. pylori. |
| Other Abstract | AIM:To evaluate the influence of oral Helicobacter pylori(H.pylori)on the success of eradication therapy against gastric H.pylori.METHODS:A total of 391 patients with dyspepsia were examined for H.pylori using the saliva H.pylori antigen test(HPS),~(13)C-urea breath test(UBT),gastroscopy,and gastric mucosal histopathological detection.Another 40 volunteers without discomfort were subjected to HPS and ~(13)C-UBT,and served as the control group.The 233 patients who were ~(13)C-UBT+were enrolled in this study and divided into 4 groups.Patients who were HPS-and ~(13)C-UBT+(n=53)received triple therapy alone.Those who were both HPS+and ~(13)CUBT+(n=180)were randomly divided into 3 groups:(1)the O+G+t group which received triple therapy alone(n=53);(2)the O+G+tm group which received both triple therapy and mouthrinse treatment(n=65);and(3)the O+G+tmp group which received triple therapy,mouthrinse,and periodontal treatment(n=62).The HPS and ~(13)C-UBT were continued for 4 wk after completion of treatment,and the eradication rate of gastric H.pylori and the prevalence of oral H.pylori in the 4 groups were then compared.RESULTS:The eradication rates of gastric H.pylori in the O-G+t group,the O+G+tm group,and the O+G+tmp group were 93.3%,90.0%,and 94.7%respectively;all of these rates were higher than that of the O+G+t group(78.4%)O-G+t group vs O+G+t group(P=0.039);O+G+tm group vs O+G+t group(P=0.092);O+G+tmp group vs O+G+t group(P=0.012);O+G+tm group vs O-G+t group(P=0.546);O+G+tmp group vs O-G+t group(P=0.765);O+G+tm group vs O+G+tmp group(P=0.924).The eradication of gastric H.pylori was significantly improved using the combination of triple therapy,mouthrinse,and periodontal treatment.The eradication rates of gastric H.pylori in the peptic ulcer group,chronic atrophic gastritis group and control group were higher than in the duodenitis group and the superficial gastritis group.The prevalence rates of oral H.pylori in the O-G+t group,O+G+t group,O+G+tm group and O+G+tmp group following treatment were 0%,76.5%,53.3%,and 50.9%,respectivelyO-G+t group vs O+G+t group(P<0.0001);O+G+tm group vs O+G+t group(P=0.011);O+G+tmp group vs O+G+t group(P=0.006);O+G+tm group vs O-G+t group(P<0.0001);O+G+tmp group vs O-G+t group(P<0.0001);O+G+tm group vs the O+G+tmp group(P=0.790).Both mouthrinse and periodontal treatment significantly reduced the prevalence of oral H.pylori.CONCLUSION:Mouthrinse treatment alone or combined with periodontal treatment can,to some extent,reduce the prevalence of oral H.pylori and improve the eradication rate of gastric H.pylori. |
| Keyword | DENTAL PLAQUE SALIVA THERAPY INFECTION STOMACH CAVITY TRANSMISSION PREVALENCE TESTS Helicobacter pylori Dental plaque Eradication Periodontal Mouthrinse |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:5009840 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/153869 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Song HanYi,Li Yan. Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori?[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19(39):6645-6650. |
| APA | Song HanYi,&Li Yan.(2013).Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori?.WORLD JOURNAL OF GASTROENTEROLOGY,19(39),6645-6650. |
| MLA | Song HanYi,et al."Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori?".WORLD JOURNAL OF GASTROENTEROLOGY 19.39(2013):6645-6650. |
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