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Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori?
Alternative TitleCan eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori ?
Song HanYi; Li Yan
2013
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume19Issue:39Pages:6645-6650
AbstractAIM: To evaluate the influence of oral Helicobacter pylori (H. pylori) on the success of eradication therapy against gastric H. pylori.
Other AbstractAIM:To evaluate the influence of oral Helicobacter pylori(H.pylori)on the success of eradication therapy against gastric H.pylori.METHODS:A total of 391 patients with dyspepsia were examined for H.pylori using the saliva H.pylori antigen test(HPS),~(13)C-urea breath test(UBT),gastroscopy,and gastric mucosal histopathological detection.Another 40 volunteers without discomfort were subjected to HPS and ~(13)C-UBT,and served as the control group.The 233 patients who were ~(13)C-UBT+were enrolled in this study and divided into 4 groups.Patients who were HPS-and ~(13)C-UBT+(n=53)received triple therapy alone.Those who were both HPS+and ~(13)CUBT+(n=180)were randomly divided into 3 groups:(1)the O+G+t group which received triple therapy alone(n=53);(2)the O+G+tm group which received both triple therapy and mouthrinse treatment(n=65);and(3)the O+G+tmp group which received triple therapy,mouthrinse,and periodontal treatment(n=62).The HPS and ~(13)C-UBT were continued for 4 wk after completion of treatment,and the eradication rate of gastric H.pylori and the prevalence of oral H.pylori in the 4 groups were then compared.RESULTS:The eradication rates of gastric H.pylori in the O-G+t group,the O+G+tm group,and the O+G+tmp group were 93.3%,90.0%,and 94.7%respectively;all of these rates were higher than that of the O+G+t group(78.4%)O-G+t group vs O+G+t group(P=0.039);O+G+tm group vs O+G+t group(P=0.092);O+G+tmp group vs O+G+t group(P=0.012);O+G+tm group vs O-G+t group(P=0.546);O+G+tmp group vs O-G+t group(P=0.765);O+G+tm group vs O+G+tmp group(P=0.924).The eradication of gastric H.pylori was significantly improved using the combination of triple therapy,mouthrinse,and periodontal treatment.The eradication rates of gastric H.pylori in the peptic ulcer group,chronic atrophic gastritis group and control group were higher than in the duodenitis group and the superficial gastritis group.The prevalence rates of oral H.pylori in the O-G+t group,O+G+t group,O+G+tm group and O+G+tmp group following treatment were 0%,76.5%,53.3%,and 50.9%,respectivelyO-G+t group vs O+G+t group(P<0.0001);O+G+tm group vs O+G+t group(P=0.011);O+G+tmp group vs O+G+t group(P=0.006);O+G+tm group vs O-G+t group(P<0.0001);O+G+tmp group vs O-G+t group(P<0.0001);O+G+tm group vs the O+G+tmp group(P=0.790).Both mouthrinse and periodontal treatment significantly reduced the prevalence of oral H.pylori.CONCLUSION:Mouthrinse treatment alone or combined with periodontal treatment can,to some extent,reduce the prevalence of oral H.pylori and improve the eradication rate of gastric H.pylori.
KeywordDENTAL PLAQUE SALIVA THERAPY INFECTION STOMACH CAVITY TRANSMISSION PREVALENCE TESTS Helicobacter pylori Dental plaque Eradication Periodontal Mouthrinse
Indexed ByCSCD
Language英语
CSCD IDCSCD:5009840
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/153869
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Song HanYi,Li Yan. Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori?[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19(39):6645-6650.
APA Song HanYi,&Li Yan.(2013).Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori?.WORLD JOURNAL OF GASTROENTEROLOGY,19(39),6645-6650.
MLA Song HanYi,et al."Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori?".WORLD JOURNAL OF GASTROENTEROLOGY 19.39(2013):6645-6650.
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