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Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents
Alternative TitleDesign,Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents
Zhang Lan; Deng Xinshan; Wu Jiaofeng; Meng Guangpeng; Liu Congchong; Chen Guzhou; Zhao Qingchun; Hu Chun
2017
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume33Issue:3Pages:365-372
AbstractA series of N-(furan-2-ylmethyl)-1H-indole-3-carboxamide derivatives(6a- 6p) was designed and synthesized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor (EGFR), and the cytotoxic activities of the target compounds were evaluated against three EGFR high- expressed cancer cell lines human lung adenocarcinoma cell line(A549), Henrietta Lacks strain of cancer cell line(HeLa) and human colorectal cancer cell line(SW480)
Other AbstractA series of N-(furan-2-ylmethyl)-1H-indole-3-carboxamide derivatives(6a-6p) was designed and synthesized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor (EGFR), and the cytotoxic activities of the target compounds were evaluated against three EGFR high-expressed cancer cell linesfhuman lung adenocarcinoma cell line(A549), Henrietta Lacks strain of cancer cell line(HeLa) and human colorectal cancer cell line(SW480)
KeywordMOLECULAR TARGETED DRUGS TYROSINE KINASE CANCER-CELLS EGFR RESISTANCE POTENT DISCOVERY NSCLC Anticancer activity Epidemal growth factor receptor(EGFR) inhibitor N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Program for the Innovative Research Team of the Ministry of Education of China]
CSCD IDCSCD:6018836
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/154007
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhang Lan,Deng Xinshan,Wu Jiaofeng,et al. Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2017,33(3):365-372.
APA Zhang Lan.,Deng Xinshan.,Wu Jiaofeng.,Meng Guangpeng.,Liu Congchong.,...&Hu Chun.(2017).Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,33(3),365-372.
MLA Zhang Lan,et al."Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 33.3(2017):365-372.
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