| Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents | |
| Alternative Title | Design,Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents |
| Zhang Lan; Deng Xinshan; Wu Jiaofeng; Meng Guangpeng; Liu Congchong; Chen Guzhou; Zhao Qingchun; Hu Chun | |
| 2017 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 33Issue:3Pages:365-372 |
| Abstract | A series of N-(furan-2-ylmethyl)-1H-indole-3-carboxamide derivatives(6a- 6p) was designed and synthesized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor (EGFR), and the cytotoxic activities of the target compounds were evaluated against three EGFR high- expressed cancer cell lines human lung adenocarcinoma cell line(A549), Henrietta Lacks strain of cancer cell line(HeLa) and human colorectal cancer cell line(SW480) |
| Other Abstract | A series of N-(furan-2-ylmethyl)-1H-indole-3-carboxamide derivatives(6a-6p) was designed and synthesized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor (EGFR), and the cytotoxic activities of the target compounds were evaluated against three EGFR high-expressed cancer cell linesfhuman lung adenocarcinoma cell line(A549), Henrietta Lacks strain of cancer cell line(HeLa) and human colorectal cancer cell line(SW480) |
| Keyword | MOLECULAR TARGETED DRUGS TYROSINE KINASE CANCER-CELLS EGFR RESISTANCE POTENT DISCOVERY NSCLC Anticancer activity Epidemal growth factor receptor(EGFR) inhibitor N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Program for the Innovative Research Team of the Ministry of Education of China] |
| CSCD ID | CSCD:6018836 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/154007 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhang Lan,Deng Xinshan,Wu Jiaofeng,et al. Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2017,33(3):365-372. |
| APA | Zhang Lan.,Deng Xinshan.,Wu Jiaofeng.,Meng Guangpeng.,Liu Congchong.,...&Hu Chun.(2017).Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,33(3),365-372. |
| MLA | Zhang Lan,et al."Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 33.3(2017):365-372. |
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