Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma

IMR OpenIR

	Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma
其他题名	Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma
	Lin Yi 1; Jin Qiang 2; Zhang Guozhen 2; Wang Yunjie 1; Jiang Tao 2; Wu Anhua 1; Wang Jiangfei 2; Qiu Xiaoguang 2
	2011
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	124 期号:19 页码:3042-3048
摘要	Background Previous studies have shown that glioma patients have lower blood IgE levels than controls. To evaluate its potential as a surrogate biomarker for glioma, we measured plasma IgE levels in glioma patients and healthy controls, and correlated them with clinicopathological factors and the patients' outcome.
其他摘要	Background: Previous studies have shown that glioma patients have lower blood IgE levels than controls. To evaluate its potential as a surrogate biomarker for glioma, we measured plasma IgE levels in glioma patients and healthy controls, and correlated them with clinicopathological factors and the patients' outcome. Methods: We used enzyme-linked immunosorbant assay (ELISA) to determine the plasma IgE levels of 25 normal subjects and 252 glioma patients (85 patients with grade II glioma, 46 patients with grade III glioma, and 121 patients with glioblastoma). We also collected longitudinal plasma samples from glioblastoma patients and compared the plasma IgE levels before operation, one week after operation, in the middle of radiotherapy, after two cycles of chemotherapy, and after recurrence. The correlations between plasma IgE levels and the outcomes of the patients were determined. Results: Plasma IgE levels were significantly lower in glioma patients (P=0.004); patients with low-grade glioma have lower IgE levels than patients with high-grade glioma do (P=0.029). In 24 patients with both preoperative plasma and two-cycle chemotherapy plasma samples, IgE levels increased after successful removal of the tumor (P=0.021), and the increase correlated with the patients' survival (increase >100 ng/ml vs. ≤100 ng/ml, 127.5 weeks vs. 62.3 weeks. P=0.012, log-rank). Plasma IgE level increase of >100 ng/ml has a specificity of 80% and a sensitivity of 78% to predict the patients' long survival (>18 months). Conclusions: Our results suggest that plasma IgE level correlates with clinical and pathological factors in glioma patients. It has the potential to be a biomarker for glioma patients.
关键词	HIGH-GRADE GLIOMAS OLIGODENDROGLIAL TUMORS IMMUNOGLOBULIN-E OVARIAN-CANCER ADULT GLIOMA RISK ALLERGY CELLS TEMOZOLOMIDE ANTIBODIES immunoglobulin E glioblastoma plasma prognosis
收录类别	CSCD
语种	英语
资助项目	[National High Technology Research and Development Program of China] ; [National Basic Research Program of China] ; [National Natural Science Foundation of China]
CSCD记录号	CSCD:4321538
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/154052
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Capital Med University, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Lin Yi,Jin Qiang,Zhang Guozhen,et al. Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma[J]. CHINESE MEDICAL JOURNAL,2011,124(19):3042-3048.
APA	Lin Yi.,Jin Qiang.,Zhang Guozhen.,Wang Yunjie.,Jiang Tao.,...&Qiu Xiaoguang.(2011).Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma.CHINESE MEDICAL JOURNAL,124(19),3042-3048.
MLA	Lin Yi,et al."Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma".CHINESE MEDICAL JOURNAL 124.19(2011):3042-3048.