IMR OpenIR
Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma
Alternative TitleIncrease of plasma IgE during treatment correlates with better outcome of patients with glioblastoma
Lin Yi1; Jin Qiang2; Zhang Guozhen2; Wang Yunjie1; Jiang Tao2; Wu Anhua1; Wang Jiangfei2; Qiu Xiaoguang2
2011
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume124Issue:19Pages:3042-3048
AbstractBackground Previous studies have shown that glioma patients have lower blood IgE levels than controls. To evaluate its potential as a surrogate biomarker for glioma, we measured plasma IgE levels in glioma patients and healthy controls, and correlated them with clinicopathological factors and the patients' outcome.
Other AbstractBackground: Previous studies have shown that glioma patients have lower blood IgE levels than controls. To evaluate its potential as a surrogate biomarker for glioma, we measured plasma IgE levels in glioma patients and healthy controls, and correlated them with clinicopathological factors and the patients' outcome. Methods: We used enzyme-linked immunosorbant assay (ELISA) to determine the plasma IgE levels of 25 normal subjects and 252 glioma patients (85 patients with grade II glioma, 46 patients with grade III glioma, and 121 patients with glioblastoma). We also collected longitudinal plasma samples from glioblastoma patients and compared the plasma IgE levels before operation, one week after operation, in the middle of radiotherapy, after two cycles of chemotherapy, and after recurrence. The correlations between plasma IgE levels and the outcomes of the patients were determined. Results: Plasma IgE levels were significantly lower in glioma patients (P=0.004); patients with low-grade glioma have lower IgE levels than patients with high-grade glioma do (P=0.029). In 24 patients with both preoperative plasma and two-cycle chemotherapy plasma samples, IgE levels increased after successful removal of the tumor (P=0.021), and the increase correlated with the patients' survival (increase >100 ng/ml vs. ≤100 ng/ml, 127.5 weeks vs. 62.3 weeks. P=0.012, log-rank). Plasma IgE level increase of >100 ng/ml has a specificity of 80% and a sensitivity of 78% to predict the patients' long survival (>18 months). Conclusions: Our results suggest that plasma IgE level correlates with clinical and pathological factors in glioma patients. It has the potential to be a biomarker for glioma patients.
KeywordHIGH-GRADE GLIOMAS OLIGODENDROGLIAL TUMORS IMMUNOGLOBULIN-E OVARIAN-CANCER ADULT GLIOMA RISK ALLERGY CELLS TEMOZOLOMIDE ANTIBODIES immunoglobulin E glioblastoma plasma prognosis
Indexed ByCSCD
Language英语
Funding Project[National High Technology Research and Development Program of China] ; [National Basic Research Program of China] ; [National Natural Science Foundation of China]
CSCD IDCSCD:4321538
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/154052
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Capital Med University, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Recommended Citation
GB/T 7714
Lin Yi,Jin Qiang,Zhang Guozhen,et al. Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma[J]. CHINESE MEDICAL JOURNAL,2011,124(19):3042-3048.
APA Lin Yi.,Jin Qiang.,Zhang Guozhen.,Wang Yunjie.,Jiang Tao.,...&Qiu Xiaoguang.(2011).Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma.CHINESE MEDICAL JOURNAL,124(19),3042-3048.
MLA Lin Yi,et al."Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma".CHINESE MEDICAL JOURNAL 124.19(2011):3042-3048.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lin Yi]'s Articles
[Jin Qiang]'s Articles
[Zhang Guozhen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lin Yi]'s Articles
[Jin Qiang]'s Articles
[Zhang Guozhen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lin Yi]'s Articles
[Jin Qiang]'s Articles
[Zhang Guozhen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.