| Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma | |
| Alternative Title | Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma |
| Lin Yi1; Jin Qiang2; Zhang Guozhen2; Wang Yunjie1; Jiang Tao2; Wu Anhua1; Wang Jiangfei2; Qiu Xiaoguang2 | |
| 2011 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 124Issue:19Pages:3042-3048 |
| Abstract | Background Previous studies have shown that glioma patients have lower blood IgE levels than controls. To evaluate its potential as a surrogate biomarker for glioma, we measured plasma IgE levels in glioma patients and healthy controls, and correlated them with clinicopathological factors and the patients' outcome. |
| Other Abstract | Background: Previous studies have shown that glioma patients have lower blood IgE levels than controls. To evaluate its potential as a surrogate biomarker for glioma, we measured plasma IgE levels in glioma patients and healthy controls, and correlated them with clinicopathological factors and the patients' outcome. Methods: We used enzyme-linked immunosorbant assay (ELISA) to determine the plasma IgE levels of 25 normal subjects and 252 glioma patients (85 patients with grade II glioma, 46 patients with grade III glioma, and 121 patients with glioblastoma). We also collected longitudinal plasma samples from glioblastoma patients and compared the plasma IgE levels before operation, one week after operation, in the middle of radiotherapy, after two cycles of chemotherapy, and after recurrence. The correlations between plasma IgE levels and the outcomes of the patients were determined. Results: Plasma IgE levels were significantly lower in glioma patients (P=0.004); patients with low-grade glioma have lower IgE levels than patients with high-grade glioma do (P=0.029). In 24 patients with both preoperative plasma and two-cycle chemotherapy plasma samples, IgE levels increased after successful removal of the tumor (P=0.021), and the increase correlated with the patients' survival (increase >100 ng/ml vs. ≤100 ng/ml, 127.5 weeks vs. 62.3 weeks. P=0.012, log-rank). Plasma IgE level increase of >100 ng/ml has a specificity of 80% and a sensitivity of 78% to predict the patients' long survival (>18 months). Conclusions: Our results suggest that plasma IgE level correlates with clinical and pathological factors in glioma patients. It has the potential to be a biomarker for glioma patients. |
| Keyword | HIGH-GRADE GLIOMAS OLIGODENDROGLIAL TUMORS IMMUNOGLOBULIN-E OVARIAN-CANCER ADULT GLIOMA RISK ALLERGY CELLS TEMOZOLOMIDE ANTIBODIES immunoglobulin E glioblastoma plasma prognosis |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National High Technology Research and Development Program of China] ; [National Basic Research Program of China] ; [National Natural Science Foundation of China] |
| CSCD ID | CSCD:4321538 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/154052 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Capital Med University, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China |
| Recommended Citation GB/T 7714 | Lin Yi,Jin Qiang,Zhang Guozhen,et al. Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma[J]. CHINESE MEDICAL JOURNAL,2011,124(19):3042-3048. |
| APA | Lin Yi.,Jin Qiang.,Zhang Guozhen.,Wang Yunjie.,Jiang Tao.,...&Qiu Xiaoguang.(2011).Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma.CHINESE MEDICAL JOURNAL,124(19),3042-3048. |
| MLA | Lin Yi,et al."Increase of plasma IgE during treatment correlates with better outcome of patients with glioblastoma".CHINESE MEDICAL JOURNAL 124.19(2011):3042-3048. |
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