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Holistic evaluation of San-Huang Tablets using a combination of multi-wavelength quantitative fingerprinting and radical-scavenging assays
Alternative TitleHolistic evaluation of San-Huang Tablets using a combination of multi-wavelength quantitative fingerprinting and radical-scavenging assays
Wang Yan1; Sun GuoXiang1; Jin Yang4; Xie XiuMan1; Liu YingChun1; Ma DiDi1; Zhang Jing1; Gao JiaYue1; Li YanFei1
2017
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
ISSN2095-6975
Volume15Issue:4Pages:310-320
AbstractThe present study was designed to establish a multi-wavelength quantitative fingerprinting method for San-Huang Tablets (SHT), a widely used and commercially available herbal preparation, where high performance liquid chromatography (HPLC) with a diode array detector (DAD) was employed to obtain the fingerprint profiles. A simple linear quantitative fingerprint method (SLQFM) coupled with multi-ingredient simultaneous determination was developed to evaluate the quality consistency of the tested samples qualitatively and quantitatively. Additionally, the component-activity relationship between chromatographic fingerprints and total radical- scavenging capacity in vitro (as assessed using the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay) was investigated by partial least squares regression (PLSR) analysis to predict the antioxidant capacity of new samples from the chromatographic fingerprints and identify the main active constituents that can be used as the target markers for the quality control of SHT. In conclusion, the strategy developed in the present study was effective and reliable, which can be employed for holistic evaluation and accurate discrimination for the quality consistency of SHT preparations and other traditional Chinese medicine (TCM) and herbal preparations as well.
Other AbstractThe present study was designed to establish a multi-wavelength quantitative fingerprinting method for San-Huang Tablets(SHT), a widely used and commercially available herbal preparation, where high performance liquid chromatography (HPLC) with a diode array detector (DAD) was employed to obtain the fingerprint profiles. A simple linear quantitative fingerprint method (SLQFM):oupled with multi-ingredient simultaneous determination was developed to evaluate the quality consistency of the tested samples qualitatively and quantitatively. Additionally, the component-activity relationship between chromatographic fingerprints and total radi-:al-scavenging capacity in vitro (as assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay) was investigated by partial least squares regression (PLSR) analysis to predict the antioxidant capacity of new samples from the chromatographic fingerprints and identify the main active constituents that can be used as the target markers for the quality control of SHT. In conclusion, the strategy developed in the present study was effective and reliable, which can be employed for holistic evaluation and accurate discrimination for the quality consistency of SHT preparations and other traditional Chinese medicine (TCM) and herbal preparations as well.
KeywordQUALITY CONSISTENCY EVALUATION HPLC FINGERPRINT SANHUANG TABLET CHROMATOGRAPHIC FINGERPRINTS ANTIOXIDANT ACTIVITY MEDICINE CHEMOMETRICS INGREDIENTS INJECTION EXTRACTS San-Huang Tablets Radical-scavenging activity Simple linear quantitative fingerprint method Quality evaluation
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Doctoral Research Fund of Dali University]
CSCD IDCSCD:5988712
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/154557
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.大理学院
3.中国科学院南京地理与湖泊研究所
4.Tradit Chinese Med Hosp Dali, Department Pharm, Dali 671000, Peoples R China Department Pharm
Recommended Citation
GB/T 7714
Wang Yan,Sun GuoXiang,Jin Yang,et al. Holistic evaluation of San-Huang Tablets using a combination of multi-wavelength quantitative fingerprinting and radical-scavenging assays[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2017,15(4):310-320.
APA Wang Yan.,Sun GuoXiang.,Jin Yang.,Xie XiuMan.,Liu YingChun.,...&Li YanFei.(2017).Holistic evaluation of San-Huang Tablets using a combination of multi-wavelength quantitative fingerprinting and radical-scavenging assays.CHINESE JOURNAL OF NATURAL MEDICINES,15(4),310-320.
MLA Wang Yan,et al."Holistic evaluation of San-Huang Tablets using a combination of multi-wavelength quantitative fingerprinting and radical-scavenging assays".CHINESE JOURNAL OF NATURAL MEDICINES 15.4(2017):310-320.
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