IMR OpenIR
Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment
Alternative TitleKappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment ☆
Chen Yu; Xiang Liangbi; Liu Jun; Zhou Dapeng; Yu Hailong; Wang Qi; Han Wenfeng; Ren Weijian
2012
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume7Issue:7Pages:523-527
AbstractThe latencies of motor- and somatosensory-evoked potentials were prolonged to different degrees, and wave amplitude was obviously decreased, after injection of dynorphin into the rat subarachnoid cavity. The wave amplitude and latencies of motor- and somatosensory-evoked potentials were significantly recovered at 7 and 14 days after combined injection of dynorphin and either the kappa opioid receptor antagonist nor-binaltorphimine or the N-methyl-D-aspartate receptor antagonist MK-801. The wave amplitude and latency were similar in rats after combined injection of dynorphin and nor-binaltorphimine or MK-801. These results suggest that intrathecal injection of dynorphin causes damage to spinal cord function. Prevention of N-methyl-D-aspartate receptor or kappa receptor activation lessened the injury to spinal cord function induced by dynorphin.
Other AbstractThe latencies of motor- and somatosensory-evoked potentials were prolonged to different degrees, and wave amplitude was obviously decreased, after injection of dynorphin into the rat subarachnoid cavity. The wave amplitude and latencies of motor- and somatosensory-evoked potentials were significantly recovered at 7 and 14 days after combined injection of dynorphin and either the kappa opioid receptor antagonist nor-binaltorphimine or the N-methyl-D-aspartate receptor antagonist MK-801. The wave amplitude and latency were similar in rats after combined injection of dynorphin and nor-binaltorphimine or MK-801. These results suggest that intrathecal injection of dynorphin causes damage to spinal cord function. Prevention of N-methyl-D-aspartate receptor or kappa receptor activation lessened the injury to spinal cord function induced by dynorphin.
KeywordEVOKED-POTENTIALS INJURY NMDA MORPHINE MK-801 TRAUMA MOTOR RATS spinal cord injury dynorphin Kappa receptor N-methyl-D-aspartate receptor motor-evoked potential somatosensory-evoked potential electrophysiology
Indexed ByCSCD
Language英语
Funding Project[Key Science and Technology Research and Development Program of Liaoning Province, China]
CSCD IDCSCD:4510578
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/154636
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Chen Yu,Xiang Liangbi,Liu Jun,et al. Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment[J]. NEURAL REGENERATION RESEARCH,2012,7(7):523-527.
APA Chen Yu.,Xiang Liangbi.,Liu Jun.,Zhou Dapeng.,Yu Hailong.,...&Ren Weijian.(2012).Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment.NEURAL REGENERATION RESEARCH,7(7),523-527.
MLA Chen Yu,et al."Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment".NEURAL REGENERATION RESEARCH 7.7(2012):523-527.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen Yu]'s Articles
[Xiang Liangbi]'s Articles
[Liu Jun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen Yu]'s Articles
[Xiang Liangbi]'s Articles
[Liu Jun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen Yu]'s Articles
[Xiang Liangbi]'s Articles
[Liu Jun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.