| Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment | |
| Alternative Title | Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment ☆ |
| Chen Yu; Xiang Liangbi; Liu Jun; Zhou Dapeng; Yu Hailong; Wang Qi; Han Wenfeng; Ren Weijian | |
| 2012 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 7Issue:7Pages:523-527 |
| Abstract | The latencies of motor- and somatosensory-evoked potentials were prolonged to different degrees, and wave amplitude was obviously decreased, after injection of dynorphin into the rat subarachnoid cavity. The wave amplitude and latencies of motor- and somatosensory-evoked potentials were significantly recovered at 7 and 14 days after combined injection of dynorphin and either the kappa opioid receptor antagonist nor-binaltorphimine or the N-methyl-D-aspartate receptor antagonist MK-801. The wave amplitude and latency were similar in rats after combined injection of dynorphin and nor-binaltorphimine or MK-801. These results suggest that intrathecal injection of dynorphin causes damage to spinal cord function. Prevention of N-methyl-D-aspartate receptor or kappa receptor activation lessened the injury to spinal cord function induced by dynorphin. |
| Other Abstract | The latencies of motor- and somatosensory-evoked potentials were prolonged to different degrees, and wave amplitude was obviously decreased, after injection of dynorphin into the rat subarachnoid cavity. The wave amplitude and latencies of motor- and somatosensory-evoked potentials were significantly recovered at 7 and 14 days after combined injection of dynorphin and either the kappa opioid receptor antagonist nor-binaltorphimine or the N-methyl-D-aspartate receptor antagonist MK-801. The wave amplitude and latency were similar in rats after combined injection of dynorphin and nor-binaltorphimine or MK-801. These results suggest that intrathecal injection of dynorphin causes damage to spinal cord function. Prevention of N-methyl-D-aspartate receptor or kappa receptor activation lessened the injury to spinal cord function induced by dynorphin. |
| Keyword | EVOKED-POTENTIALS INJURY NMDA MORPHINE MK-801 TRAUMA MOTOR RATS spinal cord injury dynorphin Kappa receptor N-methyl-D-aspartate receptor motor-evoked potential somatosensory-evoked potential electrophysiology |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Key Science and Technology Research and Development Program of Liaoning Province, China] |
| CSCD ID | CSCD:4510578 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/154636 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Chen Yu,Xiang Liangbi,Liu Jun,et al. Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment[J]. NEURAL REGENERATION RESEARCH,2012,7(7):523-527. |
| APA | Chen Yu.,Xiang Liangbi.,Liu Jun.,Zhou Dapeng.,Yu Hailong.,...&Ren Weijian.(2012).Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment.NEURAL REGENERATION RESEARCH,7(7),523-527. |
| MLA | Chen Yu,et al."Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment".NEURAL REGENERATION RESEARCH 7.7(2012):523-527. |
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