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A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation
Alternative TitleA high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation
Han Yaling; Wang Bin; Li Yi; Xu Kai; Wang Shouli; Jing Quanmin; Wang Zulu; Wang Dongmei; Ma Yingyan; Wang Geng
2009
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume122Issue:7Pages:793-797
AbstractBackground Recurrent ischemic events occurred even during routine use of 75 mg clopidogrel in addition to aspirin, that indicated a potentially insufficient maintenance dosage of clopidogrel. The aim of the present study was to evaluate the short-term efficacy and safety of a 150 mg maintenance dose of clopidogrel following a 600 mg loading dose in patients with an acute coronary syndrome (ACS) undergoing drug eluting stent (DES) implantation.
Other AbstractBackground Recurrent ischemic events occurred even during routine use of 75 mg clopidogrel in addition to aspirin, that indicated a potentially insufficient maintenance dosage of clopidogrel. The aim of the present study was to evaluate the short-term efficacy and safety of a 150 mg maintenance dose of clopidogrel following a 600 mg loading dose in patients with an acute coronary syndrome (ACS) undergoing drug eluting stent (DES) implantation. Methods Between November 2005 and November 2006, a total of 813 consecutive ACS patients undergoing DES implantation were enrolled. A 600 mg loading dose was administered before percutaneous coronary intervention (PCI) and patients were randomized to receive clopidogrel 75 mg or 150 mg for 30 days in addition to 300 mg aspirin daily. Primary end points were the composite of cardiac death, non-fatal myocardial infarction (MI) and urgent target vessel revascularization (UTVR). Secondary end points included stent thrombosis (ST), major and minor bleeding events at 30days. Results At a follow-up period of 30 days, 4 (1.0%) patients in the 150 mg group and 9 (2.2%) patients in the 75 mg group (P>0.05) reached the primary end points. There was no significant difference in the incidences of MI (0.5% vs1.2%, P>0.05), UTVR (0.7% vs 2.0%, P>0.05), and cardiac death (0.2% vs 0.2%, P>0.05) between the two groups. The incidence of ST (0 vs 1.5%, P 0.05) or minor (0.5% vs 0.2%, P>0.05) bleedings. Conclusion A high clopidogrel maintenance dose of 150 mg daily following a 600 mg loading dose for the first month after PCI procedure reduces the risk of ST and appears to be safe in patients with ACS undergoing DES implantation.
KeywordMYOCARDIAL-INFARCTION ANTIPLATELET THERAPY PLATELET-AGGREGATION ARTERY-DISEASE DIABETES-MELLITUS INTERVENTION TRIAL RESPONSIVENESS VARIABILITY INHIBITION angioplasty, transluminal, percutaneous coronary clopidogrel maintenance dose
Indexed ByCSCD
Language英语
Funding Project[Scientific and Technological Bureau of Liaoning Province]
CSCD IDCSCD:3591643
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/154736
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Han Yaling,Wang Bin,Li Yi,et al. A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation[J]. CHINESE MEDICAL JOURNAL,2009,122(7):793-797.
APA Han Yaling.,Wang Bin.,Li Yi.,Xu Kai.,Wang Shouli.,...&Wang Geng.(2009).A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation.CHINESE MEDICAL JOURNAL,122(7),793-797.
MLA Han Yaling,et al."A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation".CHINESE MEDICAL JOURNAL 122.7(2009):793-797.
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