A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation

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	A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation
其他题名	A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation
	Han Yaling; Wang Bin; Li Yi; Xu Kai; Wang Shouli; Jing Quanmin; Wang Zulu; Wang Dongmei; Ma Yingyan; Wang Geng
	2009
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	122 期号:7 页码:793-797
摘要	Background Recurrent ischemic events occurred even during routine use of 75 mg clopidogrel in addition to aspirin, that indicated a potentially insufficient maintenance dosage of clopidogrel. The aim of the present study was to evaluate the short-term efficacy and safety of a 150 mg maintenance dose of clopidogrel following a 600 mg loading dose in patients with an acute coronary syndrome (ACS) undergoing drug eluting stent (DES) implantation.
其他摘要	Background Recurrent ischemic events occurred even during routine use of 75 mg clopidogrel in addition to aspirin, that indicated a potentially insufficient maintenance dosage of clopidogrel. The aim of the present study was to evaluate the short-term efficacy and safety of a 150 mg maintenance dose of clopidogrel following a 600 mg loading dose in patients with an acute coronary syndrome (ACS) undergoing drug eluting stent (DES) implantation. Methods Between November 2005 and November 2006, a total of 813 consecutive ACS patients undergoing DES implantation were enrolled. A 600 mg loading dose was administered before percutaneous coronary intervention (PCI) and patients were randomized to receive clopidogrel 75 mg or 150 mg for 30 days in addition to 300 mg aspirin daily. Primary end points were the composite of cardiac death, non-fatal myocardial infarction (MI) and urgent target vessel revascularization (UTVR). Secondary end points included stent thrombosis (ST), major and minor bleeding events at 30days. Results At a follow-up period of 30 days, 4 (1.0%) patients in the 150 mg group and 9 (2.2%) patients in the 75 mg group (P>0.05) reached the primary end points. There was no significant difference in the incidences of MI (0.5% vs1.2%, P>0.05), UTVR (0.7% vs 2.0%, P>0.05), and cardiac death (0.2% vs 0.2%, P>0.05) between the two groups. The incidence of ST (0 vs 1.5%, P 0.05) or minor (0.5% vs 0.2%, P>0.05) bleedings. Conclusion A high clopidogrel maintenance dose of 150 mg daily following a 600 mg loading dose for the first month after PCI procedure reduces the risk of ST and appears to be safe in patients with ACS undergoing DES implantation.
关键词	MYOCARDIAL-INFARCTION ANTIPLATELET THERAPY PLATELET-AGGREGATION ARTERY-DISEASE DIABETES-MELLITUS INTERVENTION TRIAL RESPONSIVENESS VARIABILITY INHIBITION angioplasty, transluminal, percutaneous coronary clopidogrel maintenance dose
收录类别	CSCD
语种	英语
资助项目	[Scientific and Technological Bureau of Liaoning Province]
CSCD记录号	CSCD:3591643
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/154736
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Han Yaling,Wang Bin,Li Yi,et al. A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation[J]. CHINESE MEDICAL JOURNAL,2009,122(7):793-797.
APA	Han Yaling.,Wang Bin.,Li Yi.,Xu Kai.,Wang Shouli.,...&Wang Geng.(2009).A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation.CHINESE MEDICAL JOURNAL,122(7),793-797.
MLA	Han Yaling,et al."A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation".CHINESE MEDICAL JOURNAL 122.7(2009):793-797.