IMR OpenIR
Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group
Alternative TitleSynthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group
Yao Peng; Xue Hao; Liu Qian; Liu Hongtao; Chen Mingjia; Gong Ping
2010
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume26Issue:4Pages:558-562
AbstractA series of 2-amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl substituted diaryl urea derivatives was designed and synthesized. Their in vitro cytotoxicities against two cancer cell lines(Bel-7402 and A549) were evaluated by standard MTT assay. Six of tested compounds 6, 8, 10, 17, 21 and 22 exhibited more potent cytotoxicity superior to sorafenib. The structure activity relationship(SAR) study indicates that 2-amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl group was an option for cytotoxic potency.
Other AbstractA series of 2-amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl substituted diaryl urea derivatives was designed and synthesized. Their in vitro cytotoxicities against two cancer cell lines(Bel-7402 and A549) were evaluated by standard MTT assay. Six of tested compounds 6, 8, 10, 17, 21 and 22 exhibited more potent cytotoxicity superior to sorafenib. The structure activity relationship(SAR) study indicates that 2-amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl group was an option for cytotoxic potency
KeywordCCR3 ANTAGONISTS POTENT DISCOVERY DESIGN Diaryl urea 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidine Cytotoxicity
Indexed ByCSCD
Language英语
CSCD IDCSCD:4099164
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/154762
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Yao Peng,Xue Hao,Liu Qian,et al. Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2010,26(4):558-562.
APA Yao Peng,Xue Hao,Liu Qian,Liu Hongtao,Chen Mingjia,&Gong Ping.(2010).Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,26(4),558-562.
MLA Yao Peng,et al."Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 26.4(2010):558-562.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yao Peng]'s Articles
[Xue Hao]'s Articles
[Liu Qian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yao Peng]'s Articles
[Xue Hao]'s Articles
[Liu Qian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yao Peng]'s Articles
[Xue Hao]'s Articles
[Liu Qian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.