Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group

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	Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group
其他题名	Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group
	Yao Peng; Xue Hao; Liu Qian; Liu Hongtao; Chen Mingjia; Gong Ping
	2010
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	26 期号:4 页码:558-562
摘要	A series of 2-amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl substituted diaryl urea derivatives was designed and synthesized. Their in vitro cytotoxicities against two cancer cell lines(Bel-7402 and A549) were evaluated by standard MTT assay. Six of tested compounds 6, 8, 10, 17, 21 and 22 exhibited more potent cytotoxicity superior to sorafenib. The structure activity relationship(SAR) study indicates that 2-amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl group was an option for cytotoxic potency.
其他摘要	A series of 2-amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl substituted diaryl urea derivatives was designed and synthesized. Their in vitro cytotoxicities against two cancer cell lines(Bel-7402 and A549) were evaluated by standard MTT assay. Six of tested compounds 6, 8, 10, 17, 21 and 22 exhibited more potent cytotoxicity superior to sorafenib. The structure activity relationship(SAR) study indicates that 2-amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl group was an option for cytotoxic potency
关键词	CCR3 ANTAGONISTS POTENT DISCOVERY DESIGN Diaryl urea 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidine Cytotoxicity
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4099164
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/154762
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Yao Peng,Xue Hao,Liu Qian,et al. Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2010,26(4):558-562.
APA	Yao Peng,Xue Hao,Liu Qian,Liu Hongtao,Chen Mingjia,&Gong Ping.(2010).Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,26(4),558-562.
MLA	Yao Peng,et al."Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido4,3-dpyrimidinyl Group".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 26.4(2010):558-562.