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Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?
Alternative TitleWhy does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
Ge Jing1; Wang Jun1; Xue Dan1; Zhu Zhengsheng2; Chen Zhenyu1; Li Xiaoqiu1; Su Dongfeng1; Du Juan1
2013
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume8Issue:20Pages:1872-1880
AbstractChanges in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as hypertension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased expression of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.
Other AbstractChanges in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.
KeywordPHOSPHOLIPASE A(2) OXIDATIVE STRESS ISCHEMIC-STROKE ACIDS RISK COMPLICATIONS TRIGLYCERIDES METABOLISM DISEASE WOMEN neural regeneration preeclampsia eclampsia excitatory neurotransmitter neurotoxicity hyperlipidemia hypertension pregnancy lipoprotein-associated phospholipase A2 metabotropic glutamate receptor 1 grants-supported paper neuroregeneration
Indexed ByCSCD
Language英语
Funding Project[Military Medical Science and Technology General Project]
CSCD IDCSCD:4902803
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/155011
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Dantu Dist Sanit Supervis Institute, Zhenjiang 212001, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Ge Jing,Wang Jun,Xue Dan,et al. Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?[J]. NEURAL REGENERATION RESEARCH,2013,8(20):1872-1880.
APA Ge Jing.,Wang Jun.,Xue Dan.,Zhu Zhengsheng.,Chen Zhenyu.,...&Du Juan.(2013).Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?.NEURAL REGENERATION RESEARCH,8(20),1872-1880.
MLA Ge Jing,et al."Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?".NEURAL REGENERATION RESEARCH 8.20(2013):1872-1880.
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