| Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats? | |
| Alternative Title | Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats |
| Ge Jing1; Wang Jun1; Xue Dan1; Zhu Zhengsheng2; Chen Zhenyu1; Li Xiaoqiu1; Su Dongfeng1; Du Juan1 | |
| 2013 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 8Issue:20Pages:1872-1880 |
| Abstract | Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as hypertension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased expression of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats. |
| Other Abstract | Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats. |
| Keyword | PHOSPHOLIPASE A(2) OXIDATIVE STRESS ISCHEMIC-STROKE ACIDS RISK COMPLICATIONS TRIGLYCERIDES METABOLISM DISEASE WOMEN neural regeneration preeclampsia eclampsia excitatory neurotransmitter neurotoxicity hyperlipidemia hypertension pregnancy lipoprotein-associated phospholipase A2 metabotropic glutamate receptor 1 grants-supported paper neuroregeneration |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Military Medical Science and Technology General Project] |
| CSCD ID | CSCD:4902803 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/155011 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Dantu Dist Sanit Supervis Institute, Zhenjiang 212001, Jiangsu, Peoples R China |
| Recommended Citation GB/T 7714 | Ge Jing,Wang Jun,Xue Dan,et al. Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?[J]. NEURAL REGENERATION RESEARCH,2013,8(20):1872-1880. |
| APA | Ge Jing.,Wang Jun.,Xue Dan.,Zhu Zhengsheng.,Chen Zhenyu.,...&Du Juan.(2013).Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?.NEURAL REGENERATION RESEARCH,8(20),1872-1880. |
| MLA | Ge Jing,et al."Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?".NEURAL REGENERATION RESEARCH 8.20(2013):1872-1880. |
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